Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity
The function of cerebral small vessels can be assessed using cerebral vasomotor reactivity (VMR). Our aim in this retrospective cross-sectional study was to investigate a correlation between carotid artery stenosis measured through ultrasonographic morphological and hemodynamic parameters and cerebr...
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MDPI AG
2024-02-01
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| Online Access: | https://www.mdpi.com/2076-3425/14/2/167 |
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| author | Stefan Stoisavljevic Milica Stojanovic Mirjana Zdraljevic Vuk Aleksic Tatjana Pekmezovic Milija Mijajlovic |
| author_facet | Stefan Stoisavljevic Milica Stojanovic Mirjana Zdraljevic Vuk Aleksic Tatjana Pekmezovic Milija Mijajlovic |
| author_sort | Stefan Stoisavljevic |
| collection | DOAJ |
| description | The function of cerebral small vessels can be assessed using cerebral vasomotor reactivity (VMR). Our aim in this retrospective cross-sectional study was to investigate a correlation between carotid artery stenosis measured through ultrasonographic morphological and hemodynamic parameters and cerebral VMR. A total of 285 patients (125 males; mean age 54) were included. The breath-holding index (BHI) was used to evaluate cerebral VMR. Ultrasonographic carotid artery parameters were collected: the presence and characteristics of carotid plaques, the degree of carotid diameter stenosis, intima–media thickness (IMT), peak systolic velocity (PSV), and end diastolic velocity (EDV). Additionally, hemodynamic parameters of the middle cerebral artery (MCA) were evaluated, including the mean flow velocity (MFV) and pulsatility index (PI). The following was collected from patients’ medical histories: age, gender, and vascular risk factors. A negative correlation between the BHI and age (r = −0.242, <i>p</i> < 0.01), BHI and the presence of carotid plaques, BHI and IMT (r = −0.203, <i>p</i> < 0.01), and BHI and the PI of MCA on both sides (r = −0.268, <i>p</i> < 0.01) was found. We found a positive correlation between the BHI in the left MCA and EDV in the left internal carotid artery (r = 0.121, <i>p</i> < 0.05). This study shows the correlation between cerebral VMR and carotid stenosis but indicates a higher influence of morphological parameters on VMR values. |
| first_indexed | 2024-03-07T22:39:43Z |
| format | Article |
| id | doaj.art-69e65c3f950d429ab842e5d0cf51f946 |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-07T22:39:43Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-69e65c3f950d429ab842e5d0cf51f9462024-02-23T15:09:46ZengMDPI AGBrain Sciences2076-34252024-02-0114216710.3390/brainsci14020167Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor ReactivityStefan Stoisavljevic0Milica Stojanovic1Mirjana Zdraljevic2Vuk Aleksic3Tatjana Pekmezovic4Milija Mijajlovic5Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaNeurology Clinic, University Clinical Center of Serbia, 11000 Belgrade, SerbiaNeurology Clinic, University Clinical Center of Serbia, 11000 Belgrade, SerbiaNeurosurgery Department, Clinical-Hospital Center Zemun, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaThe function of cerebral small vessels can be assessed using cerebral vasomotor reactivity (VMR). Our aim in this retrospective cross-sectional study was to investigate a correlation between carotid artery stenosis measured through ultrasonographic morphological and hemodynamic parameters and cerebral VMR. A total of 285 patients (125 males; mean age 54) were included. The breath-holding index (BHI) was used to evaluate cerebral VMR. Ultrasonographic carotid artery parameters were collected: the presence and characteristics of carotid plaques, the degree of carotid diameter stenosis, intima–media thickness (IMT), peak systolic velocity (PSV), and end diastolic velocity (EDV). Additionally, hemodynamic parameters of the middle cerebral artery (MCA) were evaluated, including the mean flow velocity (MFV) and pulsatility index (PI). The following was collected from patients’ medical histories: age, gender, and vascular risk factors. A negative correlation between the BHI and age (r = −0.242, <i>p</i> < 0.01), BHI and the presence of carotid plaques, BHI and IMT (r = −0.203, <i>p</i> < 0.01), and BHI and the PI of MCA on both sides (r = −0.268, <i>p</i> < 0.01) was found. We found a positive correlation between the BHI in the left MCA and EDV in the left internal carotid artery (r = 0.121, <i>p</i> < 0.05). This study shows the correlation between cerebral VMR and carotid stenosis but indicates a higher influence of morphological parameters on VMR values.https://www.mdpi.com/2076-3425/14/2/167carotid atherosclerosiscarotid stenosiscerebral vasomotor reactivitybreath holding indexvascular risk factors |
| spellingShingle | Stefan Stoisavljevic Milica Stojanovic Mirjana Zdraljevic Vuk Aleksic Tatjana Pekmezovic Milija Mijajlovic Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity Brain Sciences carotid atherosclerosis carotid stenosis cerebral vasomotor reactivity breath holding index vascular risk factors |
| title | Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity |
| title_full | Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity |
| title_fullStr | Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity |
| title_full_unstemmed | Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity |
| title_short | Correlation between Morphological and Hemodynamic Parameters of Carotid Arteries and Cerebral Vasomotor Reactivity |
| title_sort | correlation between morphological and hemodynamic parameters of carotid arteries and cerebral vasomotor reactivity |
| topic | carotid atherosclerosis carotid stenosis cerebral vasomotor reactivity breath holding index vascular risk factors |
| url | https://www.mdpi.com/2076-3425/14/2/167 |
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