Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality
Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial s...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85426-9 |
| _version_ | 1818845850462322688 |
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| author | Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men |
| author_facet | Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men |
| author_sort | Ashaq Ali |
| collection | DOAJ |
| description | Abstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial symptoms, comorbidities and laboratory evaluation of patients, diagnosed with COVID-19 in Huoshenshan Hospital, Wuhan, from 4th February to 12th March, 2020. Based on the data collected from 63 severely ill patients from the onset of symptoms till the full recovery or demise, we found not only age (average 70) but also blood indicators as significant risk factors associated with multiple organ failure. The blood indices of all patients showed hepatic, renal, cardiac and hematopoietic dysfunction with imbalanced coagulatory biomarkers. We noticed that the levels of LDH (85%, P < .001), HBDH (76%, P < .001) and CRP (65%, P < .001) were significantly elevated in deceased patients, indicating hepatic impairment. Similarly, increased CK (15%, P = .002), Cre (37%, P = 0.102) and CysC (74%, P = 0.384) indicated renal damage. Cardiac injury was obvious from the significantly elevated level of Myoglobin (52%, P < .01), Troponin-I (65%, P = 0.273) and BNP (50%, P = .787). SARS-CoV-2 disturbs the hemolymphatic system as WBC# (73%, P = .002) and NEUT# (78%, P < .001) were significantly elevated in deceased patients. Likewise, the level of D-dimer (80%, P < .171), PT (87%, P = .031) and TT (57%, P = .053) was elevated, indicating coagulatory imbalances. We identified myoglobin and CRP as specific risk factors related to mortality and highly correlated to organ failure in COVID-19 disease. |
| first_indexed | 2024-12-19T05:36:13Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:36:13Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-69e79bb73bcb4e36b06bc36a2df150112022-12-21T20:34:09ZengNature PortfolioScientific Reports2045-23222021-03-0111111310.1038/s41598-021-85426-9Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortalityAshaq Ali0Muhammad Noman1Yong Guo2Xu Liu3Rong Zhang4Juan Zhou5Yang Zheng6Xian-En Zhang7Yong Qi8Xiaohua Chen9Dong Men10State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural UniversityDepartment of Laboratory Medicine, General Hospital of Central Theatre Command, PLADepartment of Biochemistry and Molecular Biology, Medical College, Hubei Minzu UniversityDepartment of Laboratory Medicine, General Hospital of Southern Theatre Command, PLAState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesMedical Department, General Hospital of Central Theatre Command, PLADepartment of Laboratory Medicine, General Hospital of Central Theatre Command, PLAState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesAbstract Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial symptoms, comorbidities and laboratory evaluation of patients, diagnosed with COVID-19 in Huoshenshan Hospital, Wuhan, from 4th February to 12th March, 2020. Based on the data collected from 63 severely ill patients from the onset of symptoms till the full recovery or demise, we found not only age (average 70) but also blood indicators as significant risk factors associated with multiple organ failure. The blood indices of all patients showed hepatic, renal, cardiac and hematopoietic dysfunction with imbalanced coagulatory biomarkers. We noticed that the levels of LDH (85%, P < .001), HBDH (76%, P < .001) and CRP (65%, P < .001) were significantly elevated in deceased patients, indicating hepatic impairment. Similarly, increased CK (15%, P = .002), Cre (37%, P = 0.102) and CysC (74%, P = 0.384) indicated renal damage. Cardiac injury was obvious from the significantly elevated level of Myoglobin (52%, P < .01), Troponin-I (65%, P = 0.273) and BNP (50%, P = .787). SARS-CoV-2 disturbs the hemolymphatic system as WBC# (73%, P = .002) and NEUT# (78%, P < .001) were significantly elevated in deceased patients. Likewise, the level of D-dimer (80%, P < .171), PT (87%, P = .031) and TT (57%, P = .053) was elevated, indicating coagulatory imbalances. We identified myoglobin and CRP as specific risk factors related to mortality and highly correlated to organ failure in COVID-19 disease.https://doi.org/10.1038/s41598-021-85426-9 |
| spellingShingle | Ashaq Ali Muhammad Noman Yong Guo Xu Liu Rong Zhang Juan Zhou Yang Zheng Xian-En Zhang Yong Qi Xiaohua Chen Dong Men Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality Scientific Reports |
| title | Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_full | Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_fullStr | Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_full_unstemmed | Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_short | Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality |
| title_sort | myoglobin and c reactive protein are efficient and reliable early predictors of covid 19 associated mortality |
| url | https://doi.org/10.1038/s41598-021-85426-9 |
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