Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model
<i>Curculigo orchioides</i> Gaertn. is a precious herb used in traditional medicine systems in Asian countries for various health benefits. This study investigated the potential protective effects of <i>C. orchioides</i> extract on reproductive health under heat stress condit...
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MDPI AG
2023-04-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/4/212 |
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| author | Thanh-Nhan Bui-Le Quang Hoang-Tan Huong Hoang-Viet Bich-Phuong Truong-Thi Tung Nguyen-Thanh |
| author_facet | Thanh-Nhan Bui-Le Quang Hoang-Tan Huong Hoang-Viet Bich-Phuong Truong-Thi Tung Nguyen-Thanh |
| author_sort | Thanh-Nhan Bui-Le |
| collection | DOAJ |
| description | <i>Curculigo orchioides</i> Gaertn. is a precious herb used in traditional medicine systems in Asian countries for various health benefits. This study investigated the potential protective effects of <i>C. orchioides</i> extract on reproductive health under heat stress conditions in male mice. Forty-eight mice were divided into eight groups, control condition (C group), <i>C. orchioides</i> extract at the dosages of 100, 200, and 400 mg/kg/day (C100, C200, C400 group), 40 °C heat exposure (H group), and combined 40 °C heat exposure and <i>C. orchioides</i> extract at the dosages of 100, 200, and 400 mg/kg/day (HC100, HC200, HC400 group). The result shows that the mice that received only <i>C. orchioides</i> extract without heat stress do not have a significant change in histological structure and testosterone level. The histological analysis of testicular tissue showed that heat stress conditions reduced reproductive function and inhibited the spermatogenesis of male mice. The <i>C. orchioides</i> rhizome extract treatment attenuated the heat stress-induced spermatogenesis complications in the murine model. Mice in the heat-stress group treated with <i>C. orchioides</i> extract had increased spermatogenic cells and spermatozoa compared with mice exposed to heat without <i>C. orchioides</i> treatment. Moreover, the aqueous extract of <i>C. orchioides</i> rhizome enhanced the serum total testosterone levels in heat-exposed mice. In conclusion, the study findings validate that <i>C. orchioides</i> is effective against heat stress-induced spermatogenesis complications in the murine model. |
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| language | English |
| last_indexed | 2024-03-11T05:08:03Z |
| publishDate | 2023-04-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-69e806336b9a4a109d1fc501f4acc4c32023-11-17T18:47:51ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-04-014543255326710.3390/cimb45040212Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine ModelThanh-Nhan Bui-Le0Quang Hoang-Tan1Huong Hoang-Viet2Bich-Phuong Truong-Thi3Tung Nguyen-Thanh4Faculty of Basic Science, University of Medicine and Pharmacy, Hue University, Hue 49000, VietnamInstitute of Biotechnology, Hue University, Hue 49000, VietnamThua Thien Hue Department of Science and Technology, Hue 49000, VietnamFaculty of Biology, University of Sciences, Hue University, Hue 49000, VietnamFaculty of Basic Science, University of Medicine and Pharmacy, Hue University, Hue 49000, Vietnam<i>Curculigo orchioides</i> Gaertn. is a precious herb used in traditional medicine systems in Asian countries for various health benefits. This study investigated the potential protective effects of <i>C. orchioides</i> extract on reproductive health under heat stress conditions in male mice. Forty-eight mice were divided into eight groups, control condition (C group), <i>C. orchioides</i> extract at the dosages of 100, 200, and 400 mg/kg/day (C100, C200, C400 group), 40 °C heat exposure (H group), and combined 40 °C heat exposure and <i>C. orchioides</i> extract at the dosages of 100, 200, and 400 mg/kg/day (HC100, HC200, HC400 group). The result shows that the mice that received only <i>C. orchioides</i> extract without heat stress do not have a significant change in histological structure and testosterone level. The histological analysis of testicular tissue showed that heat stress conditions reduced reproductive function and inhibited the spermatogenesis of male mice. The <i>C. orchioides</i> rhizome extract treatment attenuated the heat stress-induced spermatogenesis complications in the murine model. Mice in the heat-stress group treated with <i>C. orchioides</i> extract had increased spermatogenic cells and spermatozoa compared with mice exposed to heat without <i>C. orchioides</i> treatment. Moreover, the aqueous extract of <i>C. orchioides</i> rhizome enhanced the serum total testosterone levels in heat-exposed mice. In conclusion, the study findings validate that <i>C. orchioides</i> is effective against heat stress-induced spermatogenesis complications in the murine model.https://www.mdpi.com/1467-3045/45/4/212heat stressspermatogenesis<i>Curculigo orchioides</i>lycorine |
| spellingShingle | Thanh-Nhan Bui-Le Quang Hoang-Tan Huong Hoang-Viet Bich-Phuong Truong-Thi Tung Nguyen-Thanh Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model Current Issues in Molecular Biology heat stress spermatogenesis <i>Curculigo orchioides</i> lycorine |
| title | Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model |
| title_full | Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model |
| title_fullStr | Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model |
| title_full_unstemmed | Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model |
| title_short | Protective Effect of <i>Curculigo orchioides</i> Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model |
| title_sort | protective effect of i curculigo orchioides i gaertn extract on heat stress induced spermatogenesis complications in murine model |
| topic | heat stress spermatogenesis <i>Curculigo orchioides</i> lycorine |
| url | https://www.mdpi.com/1467-3045/45/4/212 |
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