Improvement of macrolactins production by the genetic adaptation of Bacillus siamensis A72 to saline stress via adaptive laboratory evolution

Improvement of macrolactins production by the genetic adaptation of Bacillus siamensis A72 to saline stress via adaptive laboratory evolution

Abstract Background Macrolactins, a type of macrolide antibiotic, are toxic to the producer strains. As such, its level is usually maintained below the lethal concentration during the fermentation process. To improve the production of macrolactins, we applied adaptive laboratory evolution technology...

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Bibliographic Details
Main Authors: Yuman Gan, Meng Bai, Xiao Lin, Kai Liu, Bingyao Huang, Xiaodong Jiang, Yonghong Liu, Chenghai Gao
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Microbial Cell Factories
Subjects:
Macrolactins
Adaptive laboratory evolution
Saline tolerance
Amino acid metabolism
Feedback inhibition
Online Access:https://doi.org/10.1186/s12934-022-01871-9

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