Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Abstract Background The outcome of Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remain dismal despite the development of treatment. Targeted therapy is gaining more and more attention in improving prognosis. Methods Expression of BRAF was analyzed by RT-qPCR in AML and MDS patient...

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Bibliographic Details
Main Authors: Qiao Zhou, Jiamin Zhang, Jingsong Zhang, Simin Liang, Duo Cai, Han Xiao, Yu Zhu, Wenqiong Xiang, Fernando Rodrigues-Lima, Jianxiang Chi, Fabien Guidez, Li Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Biology Direct
Subjects:
BRAF
Vemurafenib
Senescence
HIPPO signaling pathway
MDS
AML
Online Access:https://doi.org/10.1186/s13062-023-00451-0

Internet

https://doi.org/10.1186/s13062-023-00451-0

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