A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration

A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration

<p>Abstract</p> <p>Background</p> <p>HIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlyin...

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Bibliographic Details
Main Authors: Zhou Li, Pupo Gulietta M, Gupta Priyanka, Liu Bing, Tran Sieu L, Rahme Raany, Wang Bin, Rua Rejane, Rizos Helen, Carroll Adam, Cairns Murray J, Saksena Nitin K
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Genomics
Subjects:
HIV-associated dementia
Neurodegeneration
HIV
Microarray
MicroRNA
Axon guidance
Online Access:http://www.biomedcentral.com/1471-2164/13/677

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http://www.biomedcentral.com/1471-2164/13/677

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