Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw
the extracardiac actions of calcium-channel belockers has little been studied.in fact,it has been demonstrated in a number of in viro studies,that calcium-channel belockers are involved in inflammation.here,we evaluated the dose-dependent Effects of verapamil and nifedipine on carrageenan-induced, a...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
1999-09-01
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| Series: | Journal of Kerman University of Medical Sciences |
| Subjects: | |
| Online Access: | https://jkmu.kmu.ac.ir/article_34262_74dd7382eb7b05c0f7cd3a214a056237.pdf |
| _version_ | 1797790547041058816 |
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| author | M Khaksari M.A Sajadi |
| author_facet | M Khaksari M.A Sajadi |
| author_sort | M Khaksari |
| collection | DOAJ |
| description | the extracardiac actions of calcium-channel belockers has little been studied.in fact,it has been demonstrated in a number of in viro studies,that calcium-channel belockers are involved in inflammation.here,we evaluated the dose-dependent Effects of verapamil and nifedipine on carrageenan-induced, acute inflammation in the rat paw compared to the anti-inflammatory activites of ibuprofen.the adult male rats were divided into two groups.paw edema was induced by intraplantar injection of 0.1 ml of 0.5% carrageenan solution.different doses of infedipine(10,25,100,200,mg/kg) and verapamil(25,100,400,mg/lg) and ibuprofen 12 mg/lg given intrapritoneally after carrageenan injection.assessment of edema performed by calculation of volume changes and by extravasation of evans blue in test grop compared to the control,one hour after injection of carrageen.verapamil and infedipine showed significantly inhibitory effect on increased edema.maximum inhibition(83+_10%) were induced by infedipine at 100mg/kg and verapamil at 25mg/kg.nifedipine inhibited paw edema in a dose-dependent manner.the inflammation was significantly reduced(37+_5.2%) by infedipine at 200mg/lg,whereas verapamil did not have any effect.Ibuprofen reduced increased volume of paw and evans blue content by 83+_11.5% and 42+_6.3% respectively.no signifigant differences were found between inhibitory effects of nifedipine and ibuprofen.according to this results,calcium-channel blockers can inhibit acute flammatory responses in the paw,and these effects are comparable to ibuoprpfen. |
| first_indexed | 2024-03-13T02:06:09Z |
| format | Article |
| id | doaj.art-69e9c9387d5f403c8e8b95bc836b2f98 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:06:09Z |
| publishDate | 1999-09-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-69e9c9387d5f403c8e8b95bc836b2f982023-07-01T05:42:18ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28431999-09-016419119834262Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat pawM Khaksari0M.A Sajadi1Assiatant professorAssiatant professorthe extracardiac actions of calcium-channel belockers has little been studied.in fact,it has been demonstrated in a number of in viro studies,that calcium-channel belockers are involved in inflammation.here,we evaluated the dose-dependent Effects of verapamil and nifedipine on carrageenan-induced, acute inflammation in the rat paw compared to the anti-inflammatory activites of ibuprofen.the adult male rats were divided into two groups.paw edema was induced by intraplantar injection of 0.1 ml of 0.5% carrageenan solution.different doses of infedipine(10,25,100,200,mg/kg) and verapamil(25,100,400,mg/lg) and ibuprofen 12 mg/lg given intrapritoneally after carrageenan injection.assessment of edema performed by calculation of volume changes and by extravasation of evans blue in test grop compared to the control,one hour after injection of carrageen.verapamil and infedipine showed significantly inhibitory effect on increased edema.maximum inhibition(83+_10%) were induced by infedipine at 100mg/kg and verapamil at 25mg/kg.nifedipine inhibited paw edema in a dose-dependent manner.the inflammation was significantly reduced(37+_5.2%) by infedipine at 200mg/lg,whereas verapamil did not have any effect.Ibuprofen reduced increased volume of paw and evans blue content by 83+_11.5% and 42+_6.3% respectively.no signifigant differences were found between inhibitory effects of nifedipine and ibuprofen.according to this results,calcium-channel blockers can inhibit acute flammatory responses in the paw,and these effects are comparable to ibuoprpfen.https://jkmu.kmu.ac.ir/article_34262_74dd7382eb7b05c0f7cd3a214a056237.pdfverapamilnifedipineacute flammationcalcium channels blockers |
| spellingShingle | M Khaksari M.A Sajadi Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw Journal of Kerman University of Medical Sciences verapamil nifedipine acute flammation calcium channels blockers |
| title | Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw |
| title_full | Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw |
| title_fullStr | Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw |
| title_full_unstemmed | Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw |
| title_short | Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw |
| title_sort | effects of verapamil and nifedipine on carrageenan induced inflammation in the rat paw |
| topic | verapamil nifedipine acute flammation calcium channels blockers |
| url | https://jkmu.kmu.ac.ir/article_34262_74dd7382eb7b05c0f7cd3a214a056237.pdf |
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