Enhanced postoperative cancer therapy by iron-based hydrogels
Abstract Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2022-05-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-022-00268-4 |
| _version_ | 1797282626164228096 |
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| author | Haomeng Zhang Meng Zhang Xinyu Zhang Yuan Gao Yanling Ma Hongyu Chen Jipeng Wan Changzhong Li Fei Wang Xiao Sun |
| author_facet | Haomeng Zhang Meng Zhang Xinyu Zhang Yuan Gao Yanling Ma Hongyu Chen Jipeng Wan Changzhong Li Fei Wang Xiao Sun |
| author_sort | Haomeng Zhang |
| collection | DOAJ |
| description | Abstract Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine. |
| first_indexed | 2024-03-07T17:15:47Z |
| format | Article |
| id | doaj.art-69ea15f586ec475a81ef35d28b743521 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T17:15:47Z |
| publishDate | 2022-05-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-69ea15f586ec475a81ef35d28b7435212024-03-02T22:22:03ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242022-05-0126112210.1186/s40824-022-00268-4Enhanced postoperative cancer therapy by iron-based hydrogelsHaomeng Zhang0Meng Zhang1Xinyu Zhang2Yuan Gao3Yanling Ma4Hongyu Chen5Jipeng Wan6Changzhong Li7Fei Wang8Xiao Sun9Department of Gynecology, Shandong Provincial Hospital, Shandong UniversitySchool of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesSchool of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesSchool of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Chemical and Biomolecular Engineering, National University of SingaporeSchool of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Gynecology, Shandong Provincial Hospital, Shandong UniversityDepartment of Gynecology, Shandong Provincial Hospital, Shandong UniversityDepartment of Gynecology, Shandong Provincial Hospital, Shandong UniversitySchool of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesAbstract Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.https://doi.org/10.1186/s40824-022-00268-4Iron-based hydrogelsBiocompatibilitySynergistic cancer therapyPostoperative |
| spellingShingle | Haomeng Zhang Meng Zhang Xinyu Zhang Yuan Gao Yanling Ma Hongyu Chen Jipeng Wan Changzhong Li Fei Wang Xiao Sun Enhanced postoperative cancer therapy by iron-based hydrogels Biomaterials Research Iron-based hydrogels Biocompatibility Synergistic cancer therapy Postoperative |
| title | Enhanced postoperative cancer therapy by iron-based hydrogels |
| title_full | Enhanced postoperative cancer therapy by iron-based hydrogels |
| title_fullStr | Enhanced postoperative cancer therapy by iron-based hydrogels |
| title_full_unstemmed | Enhanced postoperative cancer therapy by iron-based hydrogels |
| title_short | Enhanced postoperative cancer therapy by iron-based hydrogels |
| title_sort | enhanced postoperative cancer therapy by iron based hydrogels |
| topic | Iron-based hydrogels Biocompatibility Synergistic cancer therapy Postoperative |
| url | https://doi.org/10.1186/s40824-022-00268-4 |
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