Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis
BackgroundThe pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected all age groups, including the pediatric population, in 3–5% of all cases. We performed a meta-analysis to understand the survival and associated complications in pediatric cancer pati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.608282/full |
| _version_ | 1818732272993435648 |
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| author | Elisa Dorantes-Acosta Diana Ávila-Montiel Miguel Klünder-Klünder Luis Juárez-Villegas Horacio Márquez-González Horacio Márquez-González |
| author_facet | Elisa Dorantes-Acosta Diana Ávila-Montiel Miguel Klünder-Klünder Luis Juárez-Villegas Horacio Márquez-González Horacio Márquez-González |
| author_sort | Elisa Dorantes-Acosta |
| collection | DOAJ |
| description | BackgroundThe pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected all age groups, including the pediatric population, in 3–5% of all cases. We performed a meta-analysis to understand the survival and associated complications in pediatric cancer patients as well as their hospitalization, intensive care, and ventilation care (supplemental oxygen/endotracheal intubation) needs.MethodsA systematic search was performed using MEDLINE, TRIP Database, International Clinical Trials Registry Platform (WHO), The Cochrane Library, Wiley, LILACS, and Google Scholar. Additionally, a search using the snowball method was performed in Nature, New England Journal of Medicine, Science, JAMA, ELSEVIER editorial, Oxford University Press, The Lancet, and MedRxiv. Searches were conducted until July 18, 2020. A total of 191 cancer patients with coronavirus disease 2019 (COVID-19) were integrated from 15 eligible studies. In a sub-analysis, patients were stratified into two groups: hematological cancer and solid tumors. Outcome measures were overall survival, risk of hospitalized or needing intensive care, and need for ventilatory support in any modality. The random effects statistical analysis was performed with Cochran’s chi square test. The odds ratio (OR) and heterogeneity were calculated using the I2 test.ResultsThe overall survival was 99.4%. There were no statistically significant differences in the risk of hospitalization between hematological malignancies and solid tumors (95% confidence interval [CI] 0.48–18.3; OR = 2.94). The risk of being admitted to the intensive care unit was also not different between hematological malignancies and other tumors (95% CI 0.35–5.81; OR = 1.42). No differences were found for the need of ventilatory support (95% CI 0.14–3.35; OR = 0.68). Although all the studies were cross-sectional, the mortality of these patients was 0.6% at the time of analysis.ConclusionsIn the analyzed literature, survival in the studied group of patients with COVID-19 was very high. Suffering from hematological neoplasia or other solid tumors and COVID-19 was not a risk factor in children with cancer for the analyzed outcomes. |
| first_indexed | 2024-12-17T23:30:57Z |
| format | Article |
| id | doaj.art-69eb25eec4354893b6b88f43ce04a9ed |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T23:30:57Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-69eb25eec4354893b6b88f43ce04a9ed2022-12-21T21:28:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.608282608282Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-AnalysisElisa Dorantes-Acosta0Diana Ávila-Montiel1Miguel Klünder-Klünder2Luis Juárez-Villegas3Horacio Márquez-González4Horacio Márquez-González5Biobanco de Investigación en Células Leucémicas, Hospital Infantil de México Federico Gómez, México City, MexicoSubdirección de Investigación, Hospital Infantil de México Federico Gómez, México City, MexicoSubdirección de Investigación, Hospital Infantil de México Federico Gómez, México City, MexicoDepartamento de Onco-Hematología, Hospital Infantil de México Federico Gómez, México City, MexicoInvestigación Clínica, Hospital Infantil de México Federico Gómez, México City, MexicoCardiopatías Congénitas. Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), México City, MexicoBackgroundThe pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected all age groups, including the pediatric population, in 3–5% of all cases. We performed a meta-analysis to understand the survival and associated complications in pediatric cancer patients as well as their hospitalization, intensive care, and ventilation care (supplemental oxygen/endotracheal intubation) needs.MethodsA systematic search was performed using MEDLINE, TRIP Database, International Clinical Trials Registry Platform (WHO), The Cochrane Library, Wiley, LILACS, and Google Scholar. Additionally, a search using the snowball method was performed in Nature, New England Journal of Medicine, Science, JAMA, ELSEVIER editorial, Oxford University Press, The Lancet, and MedRxiv. Searches were conducted until July 18, 2020. A total of 191 cancer patients with coronavirus disease 2019 (COVID-19) were integrated from 15 eligible studies. In a sub-analysis, patients were stratified into two groups: hematological cancer and solid tumors. Outcome measures were overall survival, risk of hospitalized or needing intensive care, and need for ventilatory support in any modality. The random effects statistical analysis was performed with Cochran’s chi square test. The odds ratio (OR) and heterogeneity were calculated using the I2 test.ResultsThe overall survival was 99.4%. There were no statistically significant differences in the risk of hospitalization between hematological malignancies and solid tumors (95% confidence interval [CI] 0.48–18.3; OR = 2.94). The risk of being admitted to the intensive care unit was also not different between hematological malignancies and other tumors (95% CI 0.35–5.81; OR = 1.42). No differences were found for the need of ventilatory support (95% CI 0.14–3.35; OR = 0.68). Although all the studies were cross-sectional, the mortality of these patients was 0.6% at the time of analysis.ConclusionsIn the analyzed literature, survival in the studied group of patients with COVID-19 was very high. Suffering from hematological neoplasia or other solid tumors and COVID-19 was not a risk factor in children with cancer for the analyzed outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2020.608282/fullsevere acute respiratory syndrome coronavirus 2coronavirus disease 2019childhood cancermeta-analysissystematic reviewmortality |
| spellingShingle | Elisa Dorantes-Acosta Diana Ávila-Montiel Miguel Klünder-Klünder Luis Juárez-Villegas Horacio Márquez-González Horacio Márquez-González Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis Frontiers in Oncology severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 childhood cancer meta-analysis systematic review mortality |
| title | Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis |
| title_full | Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis |
| title_fullStr | Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis |
| title_full_unstemmed | Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis |
| title_short | Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis |
| title_sort | survival and complications in pediatric patients with cancer and covid 19 a meta analysis |
| topic | severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 childhood cancer meta-analysis systematic review mortality |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.608282/full |
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