The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present
Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/2/160 |
| _version_ | 1797297271071571968 |
|---|---|
| author | Abul Kalam Azad Joanne Lai Wan Mohd Azizi Wan Sulaiman Hassan Almoustafa Salah Abdalrazak Alshehade Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_facet | Abul Kalam Azad Joanne Lai Wan Mohd Azizi Wan Sulaiman Hassan Almoustafa Salah Abdalrazak Alshehade Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_sort | Abul Kalam Azad |
| collection | DOAJ |
| description | Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness. There are many studies ongoing to overcome this problem. All of this motivated us to conduct this review that discusses the fabrication of polymer-based curcumin-loaded formulation as an advanced drug delivery system and addresses different approaches to overcoming the existing barriers and improving its bioavailability and biodistribution to enhance the therapeutic effects against cancer and other diseases. |
| first_indexed | 2024-03-07T22:17:54Z |
| format | Article |
| id | doaj.art-69edbc63abf94cbc9c92f0147b4e4c78 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:17:54Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-69edbc63abf94cbc9c92f0147b4e4c782024-02-23T15:30:56ZengMDPI AGPharmaceutics1999-49232024-01-0116216010.3390/pharmaceutics16020160The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the PresentAbul Kalam Azad0Joanne Lai1Wan Mohd Azizi Wan Sulaiman2Hassan Almoustafa3Salah Abdalrazak Alshehade4Vinoth Kumarasamy5Vetriselvan Subramaniyan6Faculty of Pharmacy, University College of MAIWP International, Batu Caves, Kuala Lumpur 68100, MalaysiaFaculty of Pharmacy, MAHSA University, Jenjarom 42610, Selangor, MalaysiaFaculty of Pharmacy, University College of MAIWP International, Batu Caves, Kuala Lumpur 68100, MalaysiaFaculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603, MalaysiaFaculty of Pharmacy & Bio-Medical Sciences, MAHSA University, Petaling Jaya 42610, Selangor, MalaysiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, MalaysiaPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, MalaysiaTurmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness. There are many studies ongoing to overcome this problem. All of this motivated us to conduct this review that discusses the fabrication of polymer-based curcumin-loaded formulation as an advanced drug delivery system and addresses different approaches to overcoming the existing barriers and improving its bioavailability and biodistribution to enhance the therapeutic effects against cancer and other diseases.https://www.mdpi.com/1999-4923/16/2/160curcuminencapsulationtargeted drug deliverycolon cancerabsorptionbioavailability |
| spellingShingle | Abul Kalam Azad Joanne Lai Wan Mohd Azizi Wan Sulaiman Hassan Almoustafa Salah Abdalrazak Alshehade Vinoth Kumarasamy Vetriselvan Subramaniyan The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present Pharmaceutics curcumin encapsulation targeted drug delivery colon cancer absorption bioavailability |
| title | The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present |
| title_full | The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present |
| title_fullStr | The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present |
| title_full_unstemmed | The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present |
| title_short | The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present |
| title_sort | fabrication of polymer based curcumin loaded formulation as a drug delivery system an updated review from 2017 to the present |
| topic | curcumin encapsulation targeted drug delivery colon cancer absorption bioavailability |
| url | https://www.mdpi.com/1999-4923/16/2/160 |
| work_keys_str_mv | AT abulkalamazad thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT joannelai thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT wanmohdaziziwansulaiman thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT hassanalmoustafa thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT salahabdalrazakalshehade thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT vinothkumarasamy thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT vetriselvansubramaniyan thefabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT abulkalamazad fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT joannelai fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT wanmohdaziziwansulaiman fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT hassanalmoustafa fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT salahabdalrazakalshehade fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT vinothkumarasamy fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent AT vetriselvansubramaniyan fabricationofpolymerbasedcurcuminloadedformulationasadrugdeliverysystemanupdatedreviewfrom2017tothepresent |