CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity

CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity

Abstract The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and insulin sensitivity,...

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Bibliographic Details
Main Authors: Hongxia Duan, Lin Jing, Jianquan Xiang, Chenhui Ju, Zhenzhen Wu, Jingyu Liu, Xinran Ma, Xuehui Chen, Zheng Liu, Jing Feng, Xiyun Yan
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
CD146
Gp130
macrophage polarization
obesity
Online Access:https://doi.org/10.1002/advs.202103719

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