Early development of the cochlea of the common marmoset, a non-human primate model
Abstract Background Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between ro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Neural Development |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13064-022-00162-8 |
| _version_ | 1811305888556777472 |
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| author | Makoto Hosoya Masato Fujioka Junko Okahara Sho Yoshimatsu Hideyuki Okano Hiroyuki Ozawa |
| author_facet | Makoto Hosoya Masato Fujioka Junko Okahara Sho Yoshimatsu Hideyuki Okano Hiroyuki Ozawa |
| author_sort | Makoto Hosoya |
| collection | DOAJ |
| description | Abstract Background Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between rodents and humans have been reported. To bridge these differences, we investigated early otic development of a non-human primate model animal, the common marmoset (Callithrix jacchus). Methods We examined 20 genes involved in early cochlear development and described the critical developmental steps for morphogenesis, which have been reported to vary between rodents and marmosets. Results The results revealed that several critical genes involved in prosensory epithelium specifications showed higher inter-species differences, suggesting that the molecular process for hair cell lineage acquisition in primates differs considerably from that of rodents. We also observed that the tempo of cochlear development was three times slower in the primate than in rodents. Conclusions Our data provide new insights into early cochlear development in primates and humans and imply that the procedures used for manipulating rodent cochlear sensory cells cannot be directly used for the research of primate cells due to the intrinsic inter-species differences in the cell fate determination program. |
| first_indexed | 2024-04-13T08:34:30Z |
| format | Article |
| id | doaj.art-69ef13afcc0d451e9db232bcc699315d |
| institution | Directory Open Access Journal |
| issn | 1749-8104 |
| language | English |
| last_indexed | 2024-04-13T08:34:30Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Neural Development |
| spelling | doaj.art-69ef13afcc0d451e9db232bcc699315d2022-12-22T02:54:09ZengBMCNeural Development1749-81042022-05-0117112210.1186/s13064-022-00162-8Early development of the cochlea of the common marmoset, a non-human primate modelMakoto Hosoya0Masato Fujioka1Junko Okahara2Sho Yoshimatsu3Hideyuki Okano4Hiroyuki Ozawa5Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineLaboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, 2-1 Hirosawa WakoLaboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, 2-1 Hirosawa WakoLaboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, 2-1 Hirosawa WakoDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineAbstract Background Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between rodents and humans have been reported. To bridge these differences, we investigated early otic development of a non-human primate model animal, the common marmoset (Callithrix jacchus). Methods We examined 20 genes involved in early cochlear development and described the critical developmental steps for morphogenesis, which have been reported to vary between rodents and marmosets. Results The results revealed that several critical genes involved in prosensory epithelium specifications showed higher inter-species differences, suggesting that the molecular process for hair cell lineage acquisition in primates differs considerably from that of rodents. We also observed that the tempo of cochlear development was three times slower in the primate than in rodents. Conclusions Our data provide new insights into early cochlear development in primates and humans and imply that the procedures used for manipulating rodent cochlear sensory cells cannot be directly used for the research of primate cells due to the intrinsic inter-species differences in the cell fate determination program.https://doi.org/10.1186/s13064-022-00162-8CochleaMarmosetRodentsSensory epitheliumCochlear development |
| spellingShingle | Makoto Hosoya Masato Fujioka Junko Okahara Sho Yoshimatsu Hideyuki Okano Hiroyuki Ozawa Early development of the cochlea of the common marmoset, a non-human primate model Neural Development Cochlea Marmoset Rodents Sensory epithelium Cochlear development |
| title | Early development of the cochlea of the common marmoset, a non-human primate model |
| title_full | Early development of the cochlea of the common marmoset, a non-human primate model |
| title_fullStr | Early development of the cochlea of the common marmoset, a non-human primate model |
| title_full_unstemmed | Early development of the cochlea of the common marmoset, a non-human primate model |
| title_short | Early development of the cochlea of the common marmoset, a non-human primate model |
| title_sort | early development of the cochlea of the common marmoset a non human primate model |
| topic | Cochlea Marmoset Rodents Sensory epithelium Cochlear development |
| url | https://doi.org/10.1186/s13064-022-00162-8 |
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