Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas
Glioblastoma multiforme (GBM) is the most incurable tumor (due to the difficulty in complete surgical resection and the resistance to conventional chemo/radiotherapies) that displays a high relapse frequency. Cancer stem cells (CSCs) have been considered as a promising target responsible for therapy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2054 |
| _version_ | 1797480544078921728 |
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| author | Yoshitaka Murota Kouichi Tabu Tetsuya Taga |
| author_facet | Yoshitaka Murota Kouichi Tabu Tetsuya Taga |
| author_sort | Yoshitaka Murota |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is the most incurable tumor (due to the difficulty in complete surgical resection and the resistance to conventional chemo/radiotherapies) that displays a high relapse frequency. Cancer stem cells (CSCs) have been considered as a promising target responsible for therapy resistance and cancer recurrence. CSCs are known to organize a self-advantageous microenvironment (niche) for their maintenance and expansion. Therefore, understanding how the microenvironment is reconstructed by the remaining CSCs after conventional treatments and how it eventually causes recurrence should be essential to inhibit cancer recurrence. However, the number of studies focusing on recurrence is limited, particularly those related to tumor immune microenvironment, while numerous data have been obtained from primary resected samples. Here, we summarize recent investigations on the immune microenvironment from the viewpoint of recurrent GBM (rGBM). Based on the recurrence-associated immune cell composition reported so far, we will discuss how CSCs manipulate host immunity and create the special microenvironment for themselves to regrow. An integrated understanding of the interactions between CSCs and host immune cells at the recurrent phase will lead us to develop innovative therapies and diagnoses to achieve GBM eradication. |
| first_indexed | 2024-03-09T22:01:34Z |
| format | Article |
| id | doaj.art-69f1ad072ae24975b8e9a65159690137 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:34Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-69f1ad072ae24975b8e9a651596901372023-11-23T19:48:43ZengMDPI AGCells2073-44092022-06-011113205410.3390/cells11132054Cancer Stem Cell-Associated Immune Microenvironment in Recurrent GlioblastomasYoshitaka Murota0Kouichi Tabu1Tetsuya Taga2Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, JapanGlioblastoma multiforme (GBM) is the most incurable tumor (due to the difficulty in complete surgical resection and the resistance to conventional chemo/radiotherapies) that displays a high relapse frequency. Cancer stem cells (CSCs) have been considered as a promising target responsible for therapy resistance and cancer recurrence. CSCs are known to organize a self-advantageous microenvironment (niche) for their maintenance and expansion. Therefore, understanding how the microenvironment is reconstructed by the remaining CSCs after conventional treatments and how it eventually causes recurrence should be essential to inhibit cancer recurrence. However, the number of studies focusing on recurrence is limited, particularly those related to tumor immune microenvironment, while numerous data have been obtained from primary resected samples. Here, we summarize recent investigations on the immune microenvironment from the viewpoint of recurrent GBM (rGBM). Based on the recurrence-associated immune cell composition reported so far, we will discuss how CSCs manipulate host immunity and create the special microenvironment for themselves to regrow. An integrated understanding of the interactions between CSCs and host immune cells at the recurrent phase will lead us to develop innovative therapies and diagnoses to achieve GBM eradication.https://www.mdpi.com/2073-4409/11/13/2054glioblastomarecurrencecancer stem cellimmune microenvironment |
| spellingShingle | Yoshitaka Murota Kouichi Tabu Tetsuya Taga Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas Cells glioblastoma recurrence cancer stem cell immune microenvironment |
| title | Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas |
| title_full | Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas |
| title_fullStr | Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas |
| title_full_unstemmed | Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas |
| title_short | Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas |
| title_sort | cancer stem cell associated immune microenvironment in recurrent glioblastomas |
| topic | glioblastoma recurrence cancer stem cell immune microenvironment |
| url | https://www.mdpi.com/2073-4409/11/13/2054 |
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