ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection
Summary: Autophagy and apoptosis are two recognized mechanisms of resistance to bacterial invasion. However, bacteria have likewise evolved the ability to evade immunity. In this study, we identify ACKR4a, a member of an atypical chemokine receptor family, as a suppressor of the NF-κB pathway, which...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223001827 |
| _version_ | 1828035562319118336 |
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| author | Ya Chen Baolan Cao Weiwei Zheng Tianjun Xu |
| author_facet | Ya Chen Baolan Cao Weiwei Zheng Tianjun Xu |
| author_sort | Ya Chen |
| collection | DOAJ |
| description | Summary: Autophagy and apoptosis are two recognized mechanisms of resistance to bacterial invasion. However, bacteria have likewise evolved the ability to evade immunity. In this study, we identify ACKR4a, a member of an atypical chemokine receptor family, as a suppressor of the NF-κB pathway, which cooperates with Beclin-1 to induce autophagy to inhibit NF-κB signaling and block apoptosis, facilitating Vibrio harveyi infection. Mechanistically, V. harveyi-induced Ap-1 activates ACKR4a transcription and expression. ACKR4a forms a complex with Beclin-1 and MyD88, respectively, inducing autophagy and transporting MyD88 into the lysosome for degradation to suppress inflammatory cytokine production. Meanwhile, ACKR4a-induced autophagy blocks apoptosis by inhibiting caspase8. This study proves for the first time that V. harveyi uses both autophagy and apoptosis to evade innate immunity, suggesting that V. harveyi has evolved the ability to against fish immunity. |
| first_indexed | 2024-04-10T15:47:27Z |
| format | Article |
| id | doaj.art-69f235dcb4d341ca8b91f3cfb2c3f973 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T15:47:27Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-69f235dcb4d341ca8b91f3cfb2c3f9732023-02-12T04:15:30ZengElsevieriScience2589-00422023-03-01263106105ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infectionYa Chen0Baolan Cao1Weiwei Zheng2Tianjun Xu3Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, ChinaLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, ChinaLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, ChinaLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China; Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Corresponding authorSummary: Autophagy and apoptosis are two recognized mechanisms of resistance to bacterial invasion. However, bacteria have likewise evolved the ability to evade immunity. In this study, we identify ACKR4a, a member of an atypical chemokine receptor family, as a suppressor of the NF-κB pathway, which cooperates with Beclin-1 to induce autophagy to inhibit NF-κB signaling and block apoptosis, facilitating Vibrio harveyi infection. Mechanistically, V. harveyi-induced Ap-1 activates ACKR4a transcription and expression. ACKR4a forms a complex with Beclin-1 and MyD88, respectively, inducing autophagy and transporting MyD88 into the lysosome for degradation to suppress inflammatory cytokine production. Meanwhile, ACKR4a-induced autophagy blocks apoptosis by inhibiting caspase8. This study proves for the first time that V. harveyi uses both autophagy and apoptosis to evade innate immunity, suggesting that V. harveyi has evolved the ability to against fish immunity.http://www.sciencedirect.com/science/article/pii/S2589004223001827Immune responseComponents of the immune systemBacteriology |
| spellingShingle | Ya Chen Baolan Cao Weiwei Zheng Tianjun Xu ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection iScience Immune response Components of the immune system Bacteriology |
| title | ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection |
| title_full | ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection |
| title_fullStr | ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection |
| title_full_unstemmed | ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection |
| title_short | ACKR4a induces autophagy to block NF-κB signaling and apoptosis to facilitate Vibrio harveyi infection |
| title_sort | ackr4a induces autophagy to block nf κb signaling and apoptosis to facilitate vibrio harveyi infection |
| topic | Immune response Components of the immune system Bacteriology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223001827 |
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