The tug-of-war over MTOR in Legionella infections
A ruptured bacteria-containing organelle within the cytosol of an infected eukaryotic cell frequently initiates host defense responses that restrict pathogen replication. Therefore, source for lipids must be found to accommodate the organelle membrane expansion required to support bacterial replicat...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2017-01-01
|
| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/the-tug-of-war-over-mtor-in-legionella-infections/ |
| _version_ | 1811316476649406464 |
|---|---|
| author | Stanimir S. Ivanov |
| author_facet | Stanimir S. Ivanov |
| author_sort | Stanimir S. Ivanov |
| collection | DOAJ |
| description | A ruptured bacteria-containing organelle within the cytosol of an infected eukaryotic cell frequently initiates host defense responses that restrict pathogen replication. Therefore, source for lipids must be found to accommodate the organelle membrane expansion required to support bacterial replication. How host cells are manipulated to provide lipids for the expansion of pathogen-occupied organelles is not well understood. By investigating the interaction between macrophages and the human pulmonary pathogen Legionella pneumophila we uncovered that the host metabolic checkpoint kinase Mechanistic target of rapamycin (MTOR) is a central regulator of the pathogen niche expansion program. |
| first_indexed | 2024-04-13T11:49:37Z |
| format | Article |
| id | doaj.art-69f2f7d258674dc9a42de5736a9e5610 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-13T11:49:37Z |
| publishDate | 2017-01-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-69f2f7d258674dc9a42de5736a9e56102022-12-22T02:48:05ZengShared Science Publishers OGMicrobial Cell2311-26382017-01-0142676810.15698/mic2017.02.559The tug-of-war over MTOR in Legionella infectionsStanimir S. Ivanov0Department of Microbiology and Immunology, Louisiana State University Health Sciences Center – Shreveport, Shreveport, LA 71130.A ruptured bacteria-containing organelle within the cytosol of an infected eukaryotic cell frequently initiates host defense responses that restrict pathogen replication. Therefore, source for lipids must be found to accommodate the organelle membrane expansion required to support bacterial replication. How host cells are manipulated to provide lipids for the expansion of pathogen-occupied organelles is not well understood. By investigating the interaction between macrophages and the human pulmonary pathogen Legionella pneumophila we uncovered that the host metabolic checkpoint kinase Mechanistic target of rapamycin (MTOR) is a central regulator of the pathogen niche expansion program.http://microbialcell.com/researcharticles/the-tug-of-war-over-mtor-in-legionella-infections/Legionellamacrophagelipidslipogenesisintracellular pathogensMTORPI3KSREBP |
| spellingShingle | Stanimir S. Ivanov The tug-of-war over MTOR in Legionella infections Microbial Cell Legionella macrophage lipids lipogenesis intracellular pathogens MTOR PI3K SREBP |
| title | The tug-of-war over MTOR in Legionella infections |
| title_full | The tug-of-war over MTOR in Legionella infections |
| title_fullStr | The tug-of-war over MTOR in Legionella infections |
| title_full_unstemmed | The tug-of-war over MTOR in Legionella infections |
| title_short | The tug-of-war over MTOR in Legionella infections |
| title_sort | tug of war over mtor in legionella infections |
| topic | Legionella macrophage lipids lipogenesis intracellular pathogens MTOR PI3K SREBP |
| url | http://microbialcell.com/researcharticles/the-tug-of-war-over-mtor-in-legionella-infections/ |
| work_keys_str_mv | AT stanimirsivanov thetugofwarovermtorinlegionellainfections AT stanimirsivanov tugofwarovermtorinlegionellainfections |