Dynamic modulation of mouse thalamocortical visual activity by salient sounds
Summary: Visual responses of the primary visual cortex (V1) are altered by sound. Sound-driven behavioral arousal suggests that, in addition to direct inputs from the primary auditory cortex (A1), multiple other sources may shape V1 responses to sound. Here, we show in anesthetized mice that sound (...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224005856 |
| _version_ | 1797259711282675712 |
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| author | Clément E. Lemercier Patrik Krieger Denise Manahan-Vaughan |
| author_facet | Clément E. Lemercier Patrik Krieger Denise Manahan-Vaughan |
| author_sort | Clément E. Lemercier |
| collection | DOAJ |
| description | Summary: Visual responses of the primary visual cortex (V1) are altered by sound. Sound-driven behavioral arousal suggests that, in addition to direct inputs from the primary auditory cortex (A1), multiple other sources may shape V1 responses to sound. Here, we show in anesthetized mice that sound (white noise, ≥70dB) drives a biphasic modulation of V1 visually driven gamma-band activity, comprising fast-transient inhibitory and slow, prolonged excitatory (A1-independent) arousal-driven components. An analogous yet quicker modulation of the visual response also occurred earlier in the visual pathway, at the level of the dorsolateral geniculate nucleus (dLGN), where sound transiently inhibited the early phasic visual response and subsequently induced a prolonged increase in tonic spiking activity and gamma rhythmicity. Our results demonstrate that sound-driven modulations of visual activity are not exclusive to V1 and suggest that thalamocortical inputs from the dLGN to V1 contribute to shaping V1 visual response to sound. |
| first_indexed | 2024-04-24T23:13:46Z |
| format | Article |
| id | doaj.art-69f2fccc49994368a2798a22a2ab5e95 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-24T23:13:46Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-69f2fccc49994368a2798a22a2ab5e952024-03-17T07:58:35ZengElsevieriScience2589-00422024-04-01274109364Dynamic modulation of mouse thalamocortical visual activity by salient soundsClément E. Lemercier0Patrik Krieger1Denise Manahan-Vaughan2Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany; Corresponding authorDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany; Corresponding authorSummary: Visual responses of the primary visual cortex (V1) are altered by sound. Sound-driven behavioral arousal suggests that, in addition to direct inputs from the primary auditory cortex (A1), multiple other sources may shape V1 responses to sound. Here, we show in anesthetized mice that sound (white noise, ≥70dB) drives a biphasic modulation of V1 visually driven gamma-band activity, comprising fast-transient inhibitory and slow, prolonged excitatory (A1-independent) arousal-driven components. An analogous yet quicker modulation of the visual response also occurred earlier in the visual pathway, at the level of the dorsolateral geniculate nucleus (dLGN), where sound transiently inhibited the early phasic visual response and subsequently induced a prolonged increase in tonic spiking activity and gamma rhythmicity. Our results demonstrate that sound-driven modulations of visual activity are not exclusive to V1 and suggest that thalamocortical inputs from the dLGN to V1 contribute to shaping V1 visual response to sound.http://www.sciencedirect.com/science/article/pii/S2589004224005856Natural sciencesBiological sciencesNeuroscienceSystems neuroscienceSensory neuroscience |
| spellingShingle | Clément E. Lemercier Patrik Krieger Denise Manahan-Vaughan Dynamic modulation of mouse thalamocortical visual activity by salient sounds iScience Natural sciences Biological sciences Neuroscience Systems neuroscience Sensory neuroscience |
| title | Dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| title_full | Dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| title_fullStr | Dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| title_full_unstemmed | Dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| title_short | Dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| title_sort | dynamic modulation of mouse thalamocortical visual activity by salient sounds |
| topic | Natural sciences Biological sciences Neuroscience Systems neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224005856 |
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