Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron an...

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Bibliographic Details
Main Authors: Anthony Marchand, Joyce W. M. Van Bree, Aya C. Taki, Mati Moyat, Gerardo Turcatti, Marc Chambon, Adam Alexander Thil Smith, Rory Doolan, Robin B. Gasser, Nicola Laraine Harris, Tiffany Bouchery
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
drug-screening
helminth
hookworm
blood-feeding
viability
fluorescence
Online Access:https://www.mdpi.com/1424-8247/15/6/669

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