Leptin: A Heavyweight Player in Obesity-Related Cancers
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has reached pandemic proportions and is recognized as an important health concern since it is a common root for several comorbidities, including malignancies. Indeed, the current knowledge of the white adipose tissue, w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/7/1084 |
| _version_ | 1797590100084785152 |
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| author | Amanda Caruso Luca Gelsomino Salvatore Panza Felice Maria Accattatis Giuseppina Daniela Naimo Ines Barone Cinzia Giordano Stefania Catalano Sebastiano Andò |
| author_facet | Amanda Caruso Luca Gelsomino Salvatore Panza Felice Maria Accattatis Giuseppina Daniela Naimo Ines Barone Cinzia Giordano Stefania Catalano Sebastiano Andò |
| author_sort | Amanda Caruso |
| collection | DOAJ |
| description | Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has reached pandemic proportions and is recognized as an important health concern since it is a common root for several comorbidities, including malignancies. Indeed, the current knowledge of the white adipose tissue, which shifts its role from an energy storage tissue to an important endocrine and metabolic organ, has opened up new avenues for the discovery of obesity’s effects on tumor biology. In this review, we will report the epidemiological studies concerning the strong impact of obesity in several types of cancer and describe the mechanisms underlying the heterotypic signals between cancer cell lines and adipocytes, with particular emphasis on inflammation, the insulin/IGF-1 axis, and adipokines. Among the adipokines, we will further describe the in vitro, in vivo, and clinical data concerning the role of leptin, recognized as one of the most important mediators of obesity-associated cancers. In fact, leptin physiologically regulates energy metabolism, appetite, and reproduction, and several studies have also described the role of leptin in affecting cancer development and progression. Finally, we will summarize the newest pharmacological strategies aimed at mitigating the protumorigenic effects of leptin, underlining their mechanisms of action. |
| first_indexed | 2024-03-11T01:15:38Z |
| format | Article |
| id | doaj.art-69f68c3df8064d6bbfe1ca1b0984fa60 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T01:15:38Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-69f68c3df8064d6bbfe1ca1b0984fa602023-11-18T18:31:12ZengMDPI AGBiomolecules2218-273X2023-07-01137108410.3390/biom13071084Leptin: A Heavyweight Player in Obesity-Related CancersAmanda Caruso0Luca Gelsomino1Salvatore Panza2Felice Maria Accattatis3Giuseppina Daniela Naimo4Ines Barone5Cinzia Giordano6Stefania Catalano7Sebastiano Andò8Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, Via P Bucci, University of Calabria, Arcavacata di Rende (CS), 87036 Cosenza, ItalyObesity, defined as the abnormal or excessive expansion of white adipose tissue, has reached pandemic proportions and is recognized as an important health concern since it is a common root for several comorbidities, including malignancies. Indeed, the current knowledge of the white adipose tissue, which shifts its role from an energy storage tissue to an important endocrine and metabolic organ, has opened up new avenues for the discovery of obesity’s effects on tumor biology. In this review, we will report the epidemiological studies concerning the strong impact of obesity in several types of cancer and describe the mechanisms underlying the heterotypic signals between cancer cell lines and adipocytes, with particular emphasis on inflammation, the insulin/IGF-1 axis, and adipokines. Among the adipokines, we will further describe the in vitro, in vivo, and clinical data concerning the role of leptin, recognized as one of the most important mediators of obesity-associated cancers. In fact, leptin physiologically regulates energy metabolism, appetite, and reproduction, and several studies have also described the role of leptin in affecting cancer development and progression. Finally, we will summarize the newest pharmacological strategies aimed at mitigating the protumorigenic effects of leptin, underlining their mechanisms of action.https://www.mdpi.com/2218-273X/13/7/1084obesityleptincancerscolorectallungglioma |
| spellingShingle | Amanda Caruso Luca Gelsomino Salvatore Panza Felice Maria Accattatis Giuseppina Daniela Naimo Ines Barone Cinzia Giordano Stefania Catalano Sebastiano Andò Leptin: A Heavyweight Player in Obesity-Related Cancers Biomolecules obesity leptin cancers colorectal lung glioma |
| title | Leptin: A Heavyweight Player in Obesity-Related Cancers |
| title_full | Leptin: A Heavyweight Player in Obesity-Related Cancers |
| title_fullStr | Leptin: A Heavyweight Player in Obesity-Related Cancers |
| title_full_unstemmed | Leptin: A Heavyweight Player in Obesity-Related Cancers |
| title_short | Leptin: A Heavyweight Player in Obesity-Related Cancers |
| title_sort | leptin a heavyweight player in obesity related cancers |
| topic | obesity leptin cancers colorectal lung glioma |
| url | https://www.mdpi.com/2218-273X/13/7/1084 |
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