The Role of PDE8 in T Cell Recruitment and Function in Inflammation

The Role of PDE8 in T Cell Recruitment and Function in Inflammation

Inhibitors targeting cyclic nucleotide phosphodiesterases (PDEs) expressed in leukocytes have entered clinical practice to treat inflammatory disorders, with three PDE4 inhibitors currently in clinical use as therapeutics for psoriasis, psoriatic arthritis, atopic dermatitis and chronic obstructive...

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Bibliographic Details
Main Authors: Paul M. Epstein, Chaitali Basole, Stefan Brocke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cAMP
phosphodiesterase
PDE8
Raf-1 kinase
T cell motility
leukocyte recruitment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.636778/full

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