Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium

Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium

Mitochondria-targeted antioxidants (mtAOX) are a promising treatment strategy against reactive oxygen species-induced damage. Reports about harmful effects of mtAOX lead to the question of whether these could be caused by the carrier molecule triphenylphosphonium (TPP). The aim of this study was to...

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Bibliographic Details
Main Authors: Adelheid Weidinger, Linda Birgisdóttir, Julia Schäffer, Andras T. Meszaros, Sergejs Zavadskis, Andrea Müllebner, Matthias Hecker, Johanna Catharina Duvigneau, Natascha Sommer, Andrey V. Kozlov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
mitochondria-targeted antioxidants
mitoTEMPO
TPP
lipopolysaccharide
inflammatory response
lung
Online Access:https://www.mdpi.com/2076-3921/11/2/323

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