Predicting the Area under the Plasma Concentration-Time Curve (AUC) for First Dose Vancomycin Using First-Order Pharmacokinetic Equations

Predicting the Area under the Plasma Concentration-Time Curve (AUC) for First Dose Vancomycin Using First-Order Pharmacokinetic Equations

To treat critically ill patients, early achievement of the target area under the plasma concentration-time curve/minimum inhibitory concentration (AUC/MIC) in the first 24 h is recommended. However, accurately calculating the AUC before steady state is an obstacle to this goal. A first-order pharmac...

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Bibliographic Details
Main Authors: Kritsaporn Sujjavorakul, Wasan Katip, Stephen J. Kerr, Noppadol Wacharachaisurapol, Thanyawee Puthanakit
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antibiotics
Subjects:
vancomycin
therapeutic drug monitoring
pharmacokinetics
area under the concentration curve
critically ill patients
Online Access:https://www.mdpi.com/2079-6382/12/4/630

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