cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy
The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980772/?tool=EBI |
| _version_ | 1811159908495654912 |
|---|---|
| author | Taro Misaki Shuhei Naka Hitoshi Suzuki Mingfeng Lee Ryosuke Aoki Yasuyuki Nagasawa Daiki Matsuoka Seigo Ito Ryota Nomura Michiyo Matsumoto-Nakano Yusuke Suzuki Kazuhiko Nakano |
| author_facet | Taro Misaki Shuhei Naka Hitoshi Suzuki Mingfeng Lee Ryosuke Aoki Yasuyuki Nagasawa Daiki Matsuoka Seigo Ito Ryota Nomura Michiyo Matsumoto-Nakano Yusuke Suzuki Kazuhiko Nakano |
| author_sort | Taro Misaki |
| collection | DOAJ |
| description | The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm-positive S. mutans and glomerular Gd-IgA1 in patients with IgAN. The presence of S. mutans and cnm-positive S. mutans was evaluated by polymerase chain reaction in saliva specimens from 74 patients with IgAN or IgA vasculitis. Immunofluorescent staining of IgA and Gd-IgA1 using KM55 antibody in clinical glomerular tissues was then performed. There was no significant association between the glomerular staining intensity of IgA and the positive rate of S. mutans. However, there was a significant association between the glomerular staining intensity of IgA and the positive rate of cnm-positive S. mutans (P < 0.05). There was also a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm-positive S. mutans (P < 0.05). The glomerular staining intensity of Gd-IgA1 (KM55) was not associated with the positive rate of S. mutans. These results suggest that cnm-positive S. mutans in the oral cavity is associated with the pathogenesis of Gd-IgA1 in patients with IgAN. |
| first_indexed | 2024-04-10T05:48:38Z |
| format | Article |
| id | doaj.art-69faf92b6e4f4d9c8f0a22046bdc2efa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T05:48:38Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-69faf92b6e4f4d9c8f0a22046bdc2efa2023-03-05T05:31:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathyTaro MisakiShuhei NakaHitoshi SuzukiMingfeng LeeRyosuke AokiYasuyuki NagasawaDaiki MatsuokaSeigo ItoRyota NomuraMichiyo Matsumoto-NakanoYusuke SuzukiKazuhiko NakanoThe presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm-positive S. mutans and glomerular Gd-IgA1 in patients with IgAN. The presence of S. mutans and cnm-positive S. mutans was evaluated by polymerase chain reaction in saliva specimens from 74 patients with IgAN or IgA vasculitis. Immunofluorescent staining of IgA and Gd-IgA1 using KM55 antibody in clinical glomerular tissues was then performed. There was no significant association between the glomerular staining intensity of IgA and the positive rate of S. mutans. However, there was a significant association between the glomerular staining intensity of IgA and the positive rate of cnm-positive S. mutans (P < 0.05). There was also a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm-positive S. mutans (P < 0.05). The glomerular staining intensity of Gd-IgA1 (KM55) was not associated with the positive rate of S. mutans. These results suggest that cnm-positive S. mutans in the oral cavity is associated with the pathogenesis of Gd-IgA1 in patients with IgAN.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980772/?tool=EBI |
| spellingShingle | Taro Misaki Shuhei Naka Hitoshi Suzuki Mingfeng Lee Ryosuke Aoki Yasuyuki Nagasawa Daiki Matsuoka Seigo Ito Ryota Nomura Michiyo Matsumoto-Nakano Yusuke Suzuki Kazuhiko Nakano cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy PLoS ONE |
| title | cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy |
| title_full | cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy |
| title_fullStr | cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy |
| title_full_unstemmed | cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy |
| title_short | cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy |
| title_sort | cnm positive streptococcus mutans is associated with galactose deficient iga in patients with iga nephropathy |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980772/?tool=EBI |
| work_keys_str_mv | AT taromisaki cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT shuheinaka cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT hitoshisuzuki cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT mingfenglee cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT ryosukeaoki cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT yasuyukinagasawa cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT daikimatsuoka cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT seigoito cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT ryotanomura cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT michiyomatsumotonakano cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT yusukesuzuki cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy AT kazuhikonakano cnmpositivestreptococcusmutansisassociatedwithgalactosedeficientigainpatientswithiganephropathy |