DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability

DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability

PurposesDynein axonemal assembly factor 5 (DNAAF5) is the transcription factor of regulating the cytoskeleton and hydrodynamic protein complex assembly, however, it was not well elucidated in the malignant progression of hepatocellular carcinoma (HCC).MethodsWe investigated the role of DNAAF5 in hep...

Full description

Bibliographic Details
Main Authors:	Yaping Liu, Qiong Wu, Tiantian Sun, Junxing Huang, Gaohua Han, Hexu Han
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Oncology
Subjects:	DNAAF5 glycolysis prognosis HCC PFKL protein
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1032579/full

Similar Items

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL
by: Mingang Pan, et al.
Published: (2024-01-01)

Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma
by: Xingming Zhang, et al.
Published: (2024-02-01)

A functional loop between YTH domain family protein YTHDF3 mediated m6A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinoma
by: Rong Zhou, et al.
Published: (2022-12-01)

Identification of a novel splice site mutation in the DNAAF4 gene of a Chinese patient with primary ciliary dyskinesia
by: Yang Xu, et al.
Published: (2023-01-01)

Case Report: DNAAF4 Variants Cause Primary Ciliary Dyskinesia and Infertility in Two Han Chinese Families
by: Ting Guo, et al.
Published: (2022-07-01)

Identification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia
by: Lu C, et al.
Published: (2021-11-01)

Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family
by: Guoliang Jiang, et al.
Published: (2022-12-01)

Multi-omic analysis of glycolytic signatures: exploring the predictive significance of heterogeneity and stemness in immunotherapy response and outcomes in hepatocellular carcinoma
by: Shiyu Zhang, et al.
Published: (2023-06-01)

Animal Models: A Useful Tool to Unveil Metabolic Changes in Hepatocellular Carcinoma
by: Marina Serra, et al.
Published: (2020-11-01)

Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis
by: Ya Li, et al.
Published: (2022-08-01)

A hypoxia–glycolysis–lactate-related gene signature for prognosis prediction in hepatocellular carcinoma
by: Xiaodan Qin, et al.
Published: (2024-04-01)

Based on disulfidptosis-related glycolytic genes to construct a signature for predicting prognosis and immune infiltration analysis of hepatocellular carcinoma
by: Zhijian Wang, et al.
Published: (2023-08-01)

USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1
by: Qingsong Wu, et al.
Published: (2024-02-01)

Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36
by: Weijie Sun, et al.
Published: (2022-06-01)

USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis
by: Yiyue Ren, et al.
Published: (2023-02-01)

The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma?
by: Ester Gonzalez-Sanchez, et al.
Published: (2021-06-01)

EPRS1 correlates with malignant progression in hepatocellular carcinoma
by: Chen Yang, et al.
Published: (2023-05-01)

PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression
by: Zi-Mei Peng, et al.
Published: (2024-01-01)

An Unusual Hemorrhagic Shock Caused by Spontaneous Rupture of Hepatocellular Carcinoma: A Case Report
by: Mehmet Aziret, et al.
Published: (2018-01-01)

Glycolysis : regulation, processes and diseases /
by: Lithaw, Paul N.
Published: (c200)

Long-term survival analysis of ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma conforming to the Milan criteria: primary versus recurrent HCC
by: Jing Zhang, et al.
Published: (2024-12-01)

Immune Responses Following Locoregional Treatment for Hepatocellular Carcinoma: Possible Roles of Adjuvant Immunotherapy
by: Ji-Won Han, et al.
Published: (2021-09-01)

Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives
by: Yasi Pan, et al.
Published: (2020-12-01)

Understanding the role of adipokines and adipogenesis family in hepatocellular carcinoma
by: Prithvi Singh, et al.
Published: (2023-02-01)

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC
by: Jingyi Zheng, et al.
Published: (2023-10-01)

Phosphoproteomic Analysis of the Highly-Metastatic Hepatocellular Carcinoma Cell Line, MHCC97-H
by: Miaomiao Tian, et al.
Published: (2015-02-01)

Persistent increase in alpha-fetoprotein level in a patient without underlying liver disease who underwent curative resection of hepatocellular carcinoma. A case report and review of the literature
by: Di Carlo Isidoro, et al.
Published: (2012-05-01)

Combining Sorafenib and Immunosuppression in Liver Transplant Recipients with Hepatocellular Carcinoma
by: Koen G. A. M. Hussaarts, et al.
Published: (2021-01-01)

Multicentric Fibrolamellar Hepatocellular Carcinoma: A Rare Case Report
by: Mayank Goyal, et al.
Published: (2023-01-01)

Interleukin-18 polymorphism as a diagnostic tumor marker for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis
by: Ayman Abdelghaffar Eldesoky, et al.
Published: (2020-11-01)

Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis
by: Shu Junwei, et al.
Published: (2021-01-01)

Surveillance for Hepatocellular Carcinoma in Patients with NASH
by: Philippe Kolly, et al.
Published: (2016-06-01)

Management of Hepatocellular Carcinoma in Decompensated Cirrhotic Patients: A Comprehensive Overview
by: Maria Tampaki, et al.
Published: (2023-02-01)

Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
by: Yuki Imaoka, et al.
Published: (2022-01-01)

Editorial: Identification and characterization of molecular targets in hepatocellular carcinoma
by: Vinay Kumar, et al.
Published: (2023-06-01)

Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma
by: James M. Henderson, et al.
Published: (2021-11-01)

Differential Response to Sorafenib Administration for Advanced Hepatocellular Carcinoma
by: Song-Fong Huang, et al.
Published: (2022-09-01)

Clinical and Molecular-Based Approach in the Evaluation of Hepatocellular Carcinoma Recurrence after Radical Liver Resection
by: Salvatore Gruttadauria, et al.
Published: (2021-01-01)

Genomic Relevance of <i>FGFR2</i> on the Prognosis of HCV-Induced Hepatocellular Carcinoma Patients
by: Walizeb Khan, et al.
Published: (2022-05-01)

Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma
by: Mohamed A. Abd El Aziz, et al.
Published: (2020-10-01)