Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR
Objective. Nowadays, type 2 diabetes mellitus (T2D) is the most common chronic endocrine disorder affecting an estimated 5–10% of adults worldwide, and this disease also rapidly increased among the population in the Kurdistan region. This research aims to identify DNA methylation change in the TCF7L...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-01-01
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| Series: | Endocrine Regulations |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/enr-2023-0007 |
| _version_ | 1797375936130187264 |
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| author | Smail Harem Othman Mohamad Dlnya Asaad |
| author_facet | Smail Harem Othman Mohamad Dlnya Asaad |
| author_sort | Smail Harem Othman |
| collection | DOAJ |
| description | Objective. Nowadays, type 2 diabetes mellitus (T2D) is the most common chronic endocrine disorder affecting an estimated 5–10% of adults worldwide, and this disease also rapidly increased among the population in the Kurdistan region. This research aims to identify DNA methylation change in the TCF7L2 gene as a possible predictive T2D biomarker. |
| first_indexed | 2024-03-08T19:31:27Z |
| format | Article |
| id | doaj.art-69ff187a5b29406ab1823643d9d15426 |
| institution | Directory Open Access Journal |
| issn | 1336-0329 |
| language | English |
| last_indexed | 2024-03-08T19:31:27Z |
| publishDate | 2023-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj.art-69ff187a5b29406ab1823643d9d154262023-12-26T07:42:09ZengSciendoEndocrine Regulations1336-03292023-01-01571536010.2478/enr-2023-0007Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCRSmail Harem Othman0Mohamad Dlnya Asaad11Department of Biology, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region – F.R.Iraq2Department of Biology, College of Science, University of Sulaimani, Sulaymanyah, IraqObjective. Nowadays, type 2 diabetes mellitus (T2D) is the most common chronic endocrine disorder affecting an estimated 5–10% of adults worldwide, and this disease also rapidly increased among the population in the Kurdistan region. This research aims to identify DNA methylation change in the TCF7L2 gene as a possible predictive T2D biomarker.https://doi.org/10.2478/enr-2023-0007type 2 diabetes mellitusmethylation-specific pcrtcf7l2roc curvebisulfite-converted dna |
| spellingShingle | Smail Harem Othman Mohamad Dlnya Asaad Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR Endocrine Regulations type 2 diabetes mellitus methylation-specific pcr tcf7l2 roc curve bisulfite-converted dna |
| title | Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR |
| title_full | Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR |
| title_fullStr | Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR |
| title_full_unstemmed | Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR |
| title_short | Identification of DNA methylation change in TCF7L2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in Iraq Kurdistan region by using methylation-specific PCR |
| title_sort | identification of dna methylation change in tcf7l2 gene in the blood of type 2 diabetes mellitus as a predictive biomarker in iraq kurdistan region by using methylation specific pcr |
| topic | type 2 diabetes mellitus methylation-specific pcr tcf7l2 roc curve bisulfite-converted dna |
| url | https://doi.org/10.2478/enr-2023-0007 |
| work_keys_str_mv | AT smailharemothman identificationofdnamethylationchangeintcf7l2geneinthebloodoftype2diabetesmellitusasapredictivebiomarkeriniraqkurdistanregionbyusingmethylationspecificpcr AT mohamaddlnyaasaad identificationofdnamethylationchangeintcf7l2geneinthebloodoftype2diabetesmellitusasapredictivebiomarkeriniraqkurdistanregionbyusingmethylationspecificpcr |