Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi’s sarcoma-associated herpesvirus (KSHV). To investigate the molecular mechanisms responsible for such an effect, we compared two cyt...

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Bibliographic Details
Main Authors: Marisa Granato, Maria Saveria Gilardini Montani, Camilla Angiolillo, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Viruses
Subjects:
KSHV lytic cycle
ROS
HSF1
NRF2
p62/SQSTM1
Bortezomib
TPA
butyrate
Online Access:http://www.mdpi.com/1999-4915/11/1/8

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