Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis
The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts. Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most widely used analytical technique involved i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/5/1065 |
| _version_ | 1811261736577138688 |
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| author | Moussa Yabré Ludivine Ferey Issa Touridomon Somé Karen Gaudin |
| author_facet | Moussa Yabré Ludivine Ferey Issa Touridomon Somé Karen Gaudin |
| author_sort | Moussa Yabré |
| collection | DOAJ |
| description | The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts. Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most widely used analytical technique involved in pharmaceutical drug development and manufacturing, such as the quality control of bulk drugs and pharmaceutical formulations, as well as the analysis of drugs in biological samples. However, RP-HPLC methods commonly use large amounts of organic solvents and generate high quantities of waste to be disposed, leading to some issues in terms of ecological impact and operator safety. In this context, greening HPLC methods is becoming highly desirable. One strategy to reduce the impact of hazardous solvents is to replace classically used organic solvents (i.e., acetonitrile and methanol) with greener ones. So far, ethanol has been the most often used alternative organic solvent. Others strategies have followed, such as the use of totally aqueous mobile phases, micellar liquid chromatography, and ionic liquids. These approaches have been well developed, as they do not require equipment investments and are rather economical. This review describes and critically discusses the recent advances in greening RP-HPLC methods dedicated to pharmaceutical analysis based on the use of alternative solvents. |
| first_indexed | 2024-04-12T19:11:11Z |
| format | Article |
| id | doaj.art-6a01da888b304ea4acf062b45e0557b6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T19:11:11Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6a01da888b304ea4acf062b45e0557b62022-12-22T03:19:52ZengMDPI AGMolecules1420-30492018-05-01235106510.3390/molecules23051065molecules23051065Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical AnalysisMoussa Yabré0Ludivine Ferey1Issa Touridomon Somé2Karen Gaudin3ChemBioPharm Team, ARNA Laboratory, INSERM U1212, CNRS UMR 5320, Bordeaux University, F-33000 Bordeaux, FranceChemBioPharm Team, ARNA Laboratory, INSERM U1212, CNRS UMR 5320, Bordeaux University, F-33000 Bordeaux, FranceLaboratoire de développement du médicament, Université Ouaga 1 Pr Joseph Ki-Zerbo, Ouaga 03 BP 7021, Burkina FasoChemBioPharm Team, ARNA Laboratory, INSERM U1212, CNRS UMR 5320, Bordeaux University, F-33000 Bordeaux, FranceThe greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts. Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most widely used analytical technique involved in pharmaceutical drug development and manufacturing, such as the quality control of bulk drugs and pharmaceutical formulations, as well as the analysis of drugs in biological samples. However, RP-HPLC methods commonly use large amounts of organic solvents and generate high quantities of waste to be disposed, leading to some issues in terms of ecological impact and operator safety. In this context, greening HPLC methods is becoming highly desirable. One strategy to reduce the impact of hazardous solvents is to replace classically used organic solvents (i.e., acetonitrile and methanol) with greener ones. So far, ethanol has been the most often used alternative organic solvent. Others strategies have followed, such as the use of totally aqueous mobile phases, micellar liquid chromatography, and ionic liquids. These approaches have been well developed, as they do not require equipment investments and are rather economical. This review describes and critically discusses the recent advances in greening RP-HPLC methods dedicated to pharmaceutical analysis based on the use of alternative solvents.http://www.mdpi.com/1420-3049/23/5/1065green liquid chromatographyreversed-phase chromatographyalternative solventspharmaceutical analysisethanolmicellar liquid chromatographyionic liquids |
| spellingShingle | Moussa Yabré Ludivine Ferey Issa Touridomon Somé Karen Gaudin Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis Molecules green liquid chromatography reversed-phase chromatography alternative solvents pharmaceutical analysis ethanol micellar liquid chromatography ionic liquids |
| title | Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis |
| title_full | Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis |
| title_fullStr | Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis |
| title_full_unstemmed | Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis |
| title_short | Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis |
| title_sort | greening reversed phase liquid chromatography methods using alternative solvents for pharmaceutical analysis |
| topic | green liquid chromatography reversed-phase chromatography alternative solvents pharmaceutical analysis ethanol micellar liquid chromatography ionic liquids |
| url | http://www.mdpi.com/1420-3049/23/5/1065 |
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