Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation
<p>Abstract</p> <p>Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle. Despite its fun...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | Cell Division |
| Subjects: | |
| Online Access: | http://www.celldiv.com/content/7/1/14 |
| _version_ | 1818358337634304000 |
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| author | Caillava Céline Baron-Van Evercooren Anne |
| author_facet | Caillava Céline Baron-Van Evercooren Anne |
| author_sort | Caillava Céline |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle. Despite its fundamental role, Cdk2 was found to be indispensable only in specific cell types due to molecular redundancies in its function. Converging studies highlight involvement of Cdk2 and associated cell cycle regulatory proteins in oligodendrocyte progenitor cell proliferation and differentiation. Giving the contribution of this immature cell type to brain plasticity and repair in the adult, this review will explore the requirement of Cdk2 for oligodendrogenesis, oligodendrocyte progenitor cells proliferation and differentiation during physiological and pathological conditions.</p> |
| first_indexed | 2024-12-13T20:27:24Z |
| format | Article |
| id | doaj.art-6a02328ad5854d07b3bdd3400faa5a94 |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-12-13T20:27:24Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-6a02328ad5854d07b3bdd3400faa5a942022-12-21T23:32:31ZengBMCCell Division1747-10282012-05-01711410.1186/1747-1028-7-14Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiationCaillava CélineBaron-Van Evercooren Anne<p>Abstract</p> <p>Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle. Despite its fundamental role, Cdk2 was found to be indispensable only in specific cell types due to molecular redundancies in its function. Converging studies highlight involvement of Cdk2 and associated cell cycle regulatory proteins in oligodendrocyte progenitor cell proliferation and differentiation. Giving the contribution of this immature cell type to brain plasticity and repair in the adult, this review will explore the requirement of Cdk2 for oligodendrogenesis, oligodendrocyte progenitor cells proliferation and differentiation during physiological and pathological conditions.</p>http://www.celldiv.com/content/7/1/14Cdk2ProliferationRemyelinationOligodendrocyte progenitorAdult neural stem cell |
| spellingShingle | Caillava Céline Baron-Van Evercooren Anne Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation Cell Division Cdk2 Proliferation Remyelination Oligodendrocyte progenitor Adult neural stem cell |
| title | Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| title_full | Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| title_fullStr | Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| title_full_unstemmed | Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| title_short | Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| title_sort | differential requirement of cyclin dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation |
| topic | Cdk2 Proliferation Remyelination Oligodendrocyte progenitor Adult neural stem cell |
| url | http://www.celldiv.com/content/7/1/14 |
| work_keys_str_mv | AT caillavaceline differentialrequirementofcyclindependentkinase2foroligodendrocyteprogenitorcellproliferationanddifferentiation AT baronvanevercoorenanne differentialrequirementofcyclindependentkinase2foroligodendrocyteprogenitorcellproliferationanddifferentiation |