Emerging roles of circular RNAs in cancer: a narrative review
Abstract. Circular RNAs (circRNAs) constitute a novel class of endogenous noncoding RNAs characterized by a covalently closed structure and involved in multiple biological processes. The main biological functions and properties of circRNAs can be defined by five features: a “sponging” effect on othe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2022-03-01
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| Series: | Journal of Pancreatology |
| Online Access: | http://journals.lww.com/10.1097/JP9.0000000000000087 |
| _version_ | 1798033170477613056 |
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| author | Shixiang Guo Junfeng Zhang Junyu Tao Jinfeng Zhu Ruixin Zheng Huaizhi Wang |
| author_facet | Shixiang Guo Junfeng Zhang Junyu Tao Jinfeng Zhu Ruixin Zheng Huaizhi Wang |
| author_sort | Shixiang Guo |
| collection | DOAJ |
| description | Abstract. Circular RNAs (circRNAs) constitute a novel class of endogenous noncoding RNAs characterized by a covalently closed structure and involved in multiple biological processes. The main biological functions and properties of circRNAs can be defined by five features: a “sponging” effect on other RNA species, post-transcriptional regulation, rolling circle translation, generation of pseudogenes, and splicing interference. Although circRNAs were first detected decades ago, the role of circRNAs and the mechanisms underlying their actions remain incompletely characterized. Recently, circRNAs were reported to play indispensable roles in regulating metabolic and signal transduction events controlling the proliferation, migration, and survival of cells. Importantly, many studies demonstrated that dysregulated circRNA expression is associated with the development of multiple diseases, including cancer. In this review, we summarize current knowledge on the roles and mechanisms of circRNAs in cancer and discuss their functions as oncogenes or tumor suppressors in different tumor types. |
| first_indexed | 2024-04-11T20:26:01Z |
| format | Article |
| id | doaj.art-6a025f836bf540c0ab43b3c151ff44aa |
| institution | Directory Open Access Journal |
| issn | 2096-5664 2577-3577 |
| language | English |
| last_indexed | 2024-04-11T20:26:01Z |
| publishDate | 2022-03-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Journal of Pancreatology |
| spelling | doaj.art-6a025f836bf540c0ab43b3c151ff44aa2022-12-22T04:04:40ZengWolters Kluwer Health/LWWJournal of Pancreatology2096-56642577-35772022-03-0151414710.1097/JP9.0000000000000087202203000-00006Emerging roles of circular RNAs in cancer: a narrative reviewShixiang GuoJunfeng ZhangJunyu TaoJinfeng ZhuRuixin ZhengHuaizhi WangAbstract. Circular RNAs (circRNAs) constitute a novel class of endogenous noncoding RNAs characterized by a covalently closed structure and involved in multiple biological processes. The main biological functions and properties of circRNAs can be defined by five features: a “sponging” effect on other RNA species, post-transcriptional regulation, rolling circle translation, generation of pseudogenes, and splicing interference. Although circRNAs were first detected decades ago, the role of circRNAs and the mechanisms underlying their actions remain incompletely characterized. Recently, circRNAs were reported to play indispensable roles in regulating metabolic and signal transduction events controlling the proliferation, migration, and survival of cells. Importantly, many studies demonstrated that dysregulated circRNA expression is associated with the development of multiple diseases, including cancer. In this review, we summarize current knowledge on the roles and mechanisms of circRNAs in cancer and discuss their functions as oncogenes or tumor suppressors in different tumor types.http://journals.lww.com/10.1097/JP9.0000000000000087 |
| spellingShingle | Shixiang Guo Junfeng Zhang Junyu Tao Jinfeng Zhu Ruixin Zheng Huaizhi Wang Emerging roles of circular RNAs in cancer: a narrative review Journal of Pancreatology |
| title | Emerging roles of circular RNAs in cancer: a narrative review |
| title_full | Emerging roles of circular RNAs in cancer: a narrative review |
| title_fullStr | Emerging roles of circular RNAs in cancer: a narrative review |
| title_full_unstemmed | Emerging roles of circular RNAs in cancer: a narrative review |
| title_short | Emerging roles of circular RNAs in cancer: a narrative review |
| title_sort | emerging roles of circular rnas in cancer a narrative review |
| url | http://journals.lww.com/10.1097/JP9.0000000000000087 |
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