Bone defect reconstruction via endochondral ossification: A developmental engineering strategy
Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-03-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314211004211 |
| _version_ | 1819170674743181312 |
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| author | Rao Fu Chuanqi Liu Yuxin Yan Qingfeng Li Ru-Lin Huang |
| author_facet | Rao Fu Chuanqi Liu Yuxin Yan Qingfeng Li Ru-Lin Huang |
| author_sort | Rao Fu |
| collection | DOAJ |
| description | Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside. |
| first_indexed | 2024-12-22T19:39:09Z |
| format | Article |
| id | doaj.art-6a0314cbb01d4230a69f6a74a6754501 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-22T19:39:09Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-6a0314cbb01d4230a69f6a74a67545012022-12-21T18:14:55ZengSAGE PublishingJournal of Tissue Engineering2041-73142021-03-011210.1177/20417314211004211Bone defect reconstruction via endochondral ossification: A developmental engineering strategyRao Fu0Chuanqi Liu1Yuxin Yan2Qingfeng Li3Ru-Lin Huang4Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaTraditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.https://doi.org/10.1177/20417314211004211 |
| spellingShingle | Rao Fu Chuanqi Liu Yuxin Yan Qingfeng Li Ru-Lin Huang Bone defect reconstruction via endochondral ossification: A developmental engineering strategy Journal of Tissue Engineering |
| title | Bone defect reconstruction via endochondral ossification: A developmental engineering strategy |
| title_full | Bone defect reconstruction via endochondral ossification: A developmental engineering strategy |
| title_fullStr | Bone defect reconstruction via endochondral ossification: A developmental engineering strategy |
| title_full_unstemmed | Bone defect reconstruction via endochondral ossification: A developmental engineering strategy |
| title_short | Bone defect reconstruction via endochondral ossification: A developmental engineering strategy |
| title_sort | bone defect reconstruction via endochondral ossification a developmental engineering strategy |
| url | https://doi.org/10.1177/20417314211004211 |
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