Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery
Abstract Surgical resection is the only option to achieve long-term survival in cholangiocellular carcinoma (CCA). Due to limitations of health care systems and unforeseeable events, e.g., the COVID pandemic, the time from diagnosis to surgery (time-to-surgery (TTS)) has gained great interest in mal...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50842-6 |
| _version_ | 1827377324872433664 |
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| author | Anna Mantas Dong Liu Carlos Constantin Otto Lara Rosaline Heij Daniel Heise Philipp Bruners Sven Arke Lang Tom Florian Ulmer Ulf Peter Neumann Jan Bednarsch |
| author_facet | Anna Mantas Dong Liu Carlos Constantin Otto Lara Rosaline Heij Daniel Heise Philipp Bruners Sven Arke Lang Tom Florian Ulmer Ulf Peter Neumann Jan Bednarsch |
| author_sort | Anna Mantas |
| collection | DOAJ |
| description | Abstract Surgical resection is the only option to achieve long-term survival in cholangiocellular carcinoma (CCA). Due to limitations of health care systems and unforeseeable events, e.g., the COVID pandemic, the time from diagnosis to surgery (time-to-surgery (TTS)) has gained great interest in malignancies. Thus, we investigated whether TTS is associated with the oncological outcome in patients who underwent surgery for CCA. A cohort of 276 patients undergoing curative-intent surgery for intrahepatic and perihilar CCA excluding individuals with neoadjuvant therapy and perioperative mortality between 2010 and 2021 were eligible for analysis. Patients were grouped according to TTS (≤ 30; 31–60; 61–90; > 90 days) and compared by Kruskal–Wallis-analysis. Survival was compared using Kaplan–Meier analysis and characteristics associated with cancer-specific survival (CSS), recurrence-free survival (RFS) and overall survival (OS) using Cox regressions. The median CSS was 39 months (3-year-CSS = 52%, 5-year-CSS = 42%) and the median RFS 20 months (3-year-CSS = 38%, 5-year-CSS = 33%). In univariable Cox regressions, TTS was not associated with CSS (p = 0.971) or RFS (p = 0.855), respectively. A grouped analysis with respect to TTS (≤ 30 days, n = 106; 31–60 days, n = 134; 61–90 days, n = 44; > 90 days, n = 29) displayed a median CSS of 38, 33, 51 and 41 months and median RFS of 17, 22, 28 and 20 months (p = 0.971 log rank; p = 0.520 log rank). No statistical difference regarding oncological risk factors were observed between the groups. This study is the first comprehensive analysis of TTS in CCA patients. Within a representative European cohort, TTS was not associated with earlier tumor recurrence or reduced CCS. |
| first_indexed | 2024-03-08T12:37:28Z |
| format | Article |
| id | doaj.art-6a034514f3da4fbca4e2e0f61086fd29 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T12:37:28Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6a034514f3da4fbca4e2e0f61086fd292024-01-21T12:21:28ZengNature PortfolioScientific Reports2045-23222024-01-0114111310.1038/s41598-023-50842-6Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgeryAnna Mantas0Dong Liu1Carlos Constantin Otto2Lara Rosaline Heij3Daniel Heise4Philipp Bruners5Sven Arke Lang6Tom Florian Ulmer7Ulf Peter Neumann8Jan Bednarsch9Department of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenDepartment of Surgery and Transplantation, University Hospital RWTH AachenAbstract Surgical resection is the only option to achieve long-term survival in cholangiocellular carcinoma (CCA). Due to limitations of health care systems and unforeseeable events, e.g., the COVID pandemic, the time from diagnosis to surgery (time-to-surgery (TTS)) has gained great interest in malignancies. Thus, we investigated whether TTS is associated with the oncological outcome in patients who underwent surgery for CCA. A cohort of 276 patients undergoing curative-intent surgery for intrahepatic and perihilar CCA excluding individuals with neoadjuvant therapy and perioperative mortality between 2010 and 2021 were eligible for analysis. Patients were grouped according to TTS (≤ 30; 31–60; 61–90; > 90 days) and compared by Kruskal–Wallis-analysis. Survival was compared using Kaplan–Meier analysis and characteristics associated with cancer-specific survival (CSS), recurrence-free survival (RFS) and overall survival (OS) using Cox regressions. The median CSS was 39 months (3-year-CSS = 52%, 5-year-CSS = 42%) and the median RFS 20 months (3-year-CSS = 38%, 5-year-CSS = 33%). In univariable Cox regressions, TTS was not associated with CSS (p = 0.971) or RFS (p = 0.855), respectively. A grouped analysis with respect to TTS (≤ 30 days, n = 106; 31–60 days, n = 134; 61–90 days, n = 44; > 90 days, n = 29) displayed a median CSS of 38, 33, 51 and 41 months and median RFS of 17, 22, 28 and 20 months (p = 0.971 log rank; p = 0.520 log rank). No statistical difference regarding oncological risk factors were observed between the groups. This study is the first comprehensive analysis of TTS in CCA patients. Within a representative European cohort, TTS was not associated with earlier tumor recurrence or reduced CCS.https://doi.org/10.1038/s41598-023-50842-6 |
| spellingShingle | Anna Mantas Dong Liu Carlos Constantin Otto Lara Rosaline Heij Daniel Heise Philipp Bruners Sven Arke Lang Tom Florian Ulmer Ulf Peter Neumann Jan Bednarsch Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery Scientific Reports |
| title | Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery |
| title_full | Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery |
| title_fullStr | Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery |
| title_full_unstemmed | Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery |
| title_short | Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery |
| title_sort | time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative intent liver surgery |
| url | https://doi.org/10.1038/s41598-023-50842-6 |
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