Computational Design of Miniproteins as SARS-CoV-2 Therapeutic Inhibitors

Computational Design of Miniproteins as SARS-CoV-2 Therapeutic Inhibitors

A rational therapeutic strategy is urgently needed for combating SARS-CoV-2 infection. Viral infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 receptor, and thus, inhibiting RBD is a promising therapeutic for blocking viral entry. In this study, the structure of...

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Bibliographic Details
Main Authors:	Bahaa Jawad, Puja Adhikari, Kun Cheng, Rudolf Podgornik, Wai-Yim Ching
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	International Journal of Molecular Sciences
Subjects:	SARS-CoV-2 therapeutics design miniprotein inhibitors modification molecular dynamics simulation density functional calculation
Online Access:	https://www.mdpi.com/1422-0067/23/2/838

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