Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia
Objective: To determine the differences in coagulation features in patients with severe versus non-severe COVID-19. Method: During the period of the study from July 2020 to June 2021, 371 COVID-19 patients were treated at Dr. Hasan Sadikin Hospital. These patients were divided into two groups base...
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2023-09-01
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| Series: | International Journal of Integrated Health Sciences |
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| Online Access: | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2976 |
| _version_ | 1797449286392217600 |
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| author | Pandji Irani Fianza Delita Prihatni Dasep Bambang Purnama |
| author_facet | Pandji Irani Fianza Delita Prihatni Dasep Bambang Purnama |
| author_sort | Pandji Irani Fianza |
| collection | DOAJ |
| description | Objective: To determine the differences in coagulation features in patients with severe versus non-severe COVID-19.
Method: During the period of the study from July 2020 to June 2021, 371 COVID-19 patients were treated at Dr. Hasan Sadikin Hospital. These patients were divided into two groups based on the WHO critera into severe COVID-19 with clinical signs such as severe acute respiratory syndrome to respiratory failure and non-severe cases with no respiratory symptoms. Data analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), International Normalized Ratio (INR), fibrinogen, D-dimer, and platelet count.
Results: Median INR was significantly higher in patients with severe cases than in non-severe cases (1.04 vs. 0.94, p<0.001), which was also true for median PT (12.3 vs. 12.0 sec, p=0.030) and median fibrinogen (522 vs. 428.5 mg/dl, p=0.004). Similarly, the median D-dimer was significantly higher in severe patients (1.91 vs. 0.75 mg/dl, p<0.001). Median aPTT and platelet count were in normal limits for both severe and non-severe COVID-19 patients (28.6 vs. 29.15 sec, p>0.652 and 246 vs. 242 x103/mm3, p>0.924, respectively).
Conclusions: The INR, PT, fibrinogen, and D-dimer can be considered as features that can be used to predict the severity of the disease and to choose the proper treatment for COVID-19 patients. |
| first_indexed | 2024-03-09T14:22:44Z |
| format | Article |
| id | doaj.art-6a06f491e5644498be82e375e84d6236 |
| institution | Directory Open Access Journal |
| issn | 2302-1381 2338-4506 |
| language | English |
| last_indexed | 2024-03-09T14:22:44Z |
| publishDate | 2023-09-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | International Journal of Integrated Health Sciences |
| spelling | doaj.art-6a06f491e5644498be82e375e84d62362023-11-28T09:18:09ZengUniversitas PadjadjaranInternational Journal of Integrated Health Sciences2302-13812338-45062023-09-0111210711110.15850/ijihs.v11n2.29671636Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in IndonesiaPandji Irani Fianza0Delita Prihatni1Dasep Bambang Purnama2Department Internal Medicine Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital BandungDepartment of Clinical Pathology Faculty of Medicine Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital BandungDepartment Internal Medicine Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital BandungObjective: To determine the differences in coagulation features in patients with severe versus non-severe COVID-19. Method: During the period of the study from July 2020 to June 2021, 371 COVID-19 patients were treated at Dr. Hasan Sadikin Hospital. These patients were divided into two groups based on the WHO critera into severe COVID-19 with clinical signs such as severe acute respiratory syndrome to respiratory failure and non-severe cases with no respiratory symptoms. Data analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), International Normalized Ratio (INR), fibrinogen, D-dimer, and platelet count. Results: Median INR was significantly higher in patients with severe cases than in non-severe cases (1.04 vs. 0.94, p<0.001), which was also true for median PT (12.3 vs. 12.0 sec, p=0.030) and median fibrinogen (522 vs. 428.5 mg/dl, p=0.004). Similarly, the median D-dimer was significantly higher in severe patients (1.91 vs. 0.75 mg/dl, p<0.001). Median aPTT and platelet count were in normal limits for both severe and non-severe COVID-19 patients (28.6 vs. 29.15 sec, p>0.652 and 246 vs. 242 x103/mm3, p>0.924, respectively). Conclusions: The INR, PT, fibrinogen, and D-dimer can be considered as features that can be used to predict the severity of the disease and to choose the proper treatment for COVID-19 patients.https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2976coagulopathy disorders, covid-19, severe acute respiratory syndrome, non-severe acute respiratory syndrome |
| spellingShingle | Pandji Irani Fianza Delita Prihatni Dasep Bambang Purnama Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia International Journal of Integrated Health Sciences coagulopathy disorders, covid-19, severe acute respiratory syndrome, non-severe acute respiratory syndrome |
| title | Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia |
| title_full | Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia |
| title_fullStr | Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia |
| title_full_unstemmed | Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia |
| title_short | Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia |
| title_sort | comparison of coagulation parameters between severe and non severe covid 19 patients treated in a tertiary hospital in indonesia |
| topic | coagulopathy disorders, covid-19, severe acute respiratory syndrome, non-severe acute respiratory syndrome |
| url | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2976 |
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