Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence
BACKGROUND: Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%. OBJECTIVES: To compare the safety and efficacy of topical cyclosporine A (CsA)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Oman Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=1;spage=30;epage=34;aulast=Raina |
| _version_ | 1827986023045398528 |
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| author | Usha K Raina Banu Pavitra Shruti Bhattacharya Kumar Ravinesh Ruchi Goel |
| author_facet | Usha K Raina Banu Pavitra Shruti Bhattacharya Kumar Ravinesh Ruchi Goel |
| author_sort | Usha K Raina |
| collection | DOAJ |
| description | BACKGROUND: Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%.
OBJECTIVES: To compare the safety and efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b in the prevention of postoperative recurrence of pterygium.
METHODS: A total of 40 patients with primary pterygium were randomized into two equal groups, Group C and Group I. Both the groups underwent LCAT, with Group C kept on topical cyclosporine 0.05% (CsA) 4 times daily and Group I on topical IFN alpha 2b 0.2 million IU 4 times daily postoperatively for 3 months. Pre- and posttreatment best-corrected visual acuity (BCVA), recurrence, and complications were assessed at day 1, week 1, 1 month, and 3 months.
RESULTS: The mean preoperative BCVA of 0.51 ± 0.18 and 0.51 ± 0.23 improved to 0.13 ± 0.13 and 0.13 ± 0.13 in Group C and Group I, respectively, after 3 months of treatment (P < 0.0001). Recurrence was seen in 2 cases in Group C and in 1 case in Group I at 3 months. No significant complications occurred in either of the groups.
CONCLUSION: Topical CsA and IFN Alpha-2b are newer efficacious adjuvants with LCAT for prevention of postoperative pterygium recurrence. |
| first_indexed | 2024-04-09T23:24:07Z |
| format | Article |
| id | doaj.art-6a0bf0f9fc6e4fbdb51f1824c8ba8f82 |
| institution | Directory Open Access Journal |
| issn | 0974-620X |
| language | English |
| last_indexed | 2024-04-09T23:24:07Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Oman Journal of Ophthalmology |
| spelling | doaj.art-6a0bf0f9fc6e4fbdb51f1824c8ba8f822023-03-21T11:25:38ZengWolters Kluwer Medknow PublicationsOman Journal of Ophthalmology0974-620X2023-01-01161303410.4103/ojo.ojo_56_22Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrenceUsha K RainaBanu PavitraShruti BhattacharyaKumar RavineshRuchi GoelBACKGROUND: Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%. OBJECTIVES: To compare the safety and efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b in the prevention of postoperative recurrence of pterygium. METHODS: A total of 40 patients with primary pterygium were randomized into two equal groups, Group C and Group I. Both the groups underwent LCAT, with Group C kept on topical cyclosporine 0.05% (CsA) 4 times daily and Group I on topical IFN alpha 2b 0.2 million IU 4 times daily postoperatively for 3 months. Pre- and posttreatment best-corrected visual acuity (BCVA), recurrence, and complications were assessed at day 1, week 1, 1 month, and 3 months. RESULTS: The mean preoperative BCVA of 0.51 ± 0.18 and 0.51 ± 0.23 improved to 0.13 ± 0.13 and 0.13 ± 0.13 in Group C and Group I, respectively, after 3 months of treatment (P < 0.0001). Recurrence was seen in 2 cases in Group C and in 1 case in Group I at 3 months. No significant complications occurred in either of the groups. CONCLUSION: Topical CsA and IFN Alpha-2b are newer efficacious adjuvants with LCAT for prevention of postoperative pterygium recurrence.http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=1;spage=30;epage=34;aulast=Rainacyclosporineinterferonlimbal conjunctival autograftpterygium |
| spellingShingle | Usha K Raina Banu Pavitra Shruti Bhattacharya Kumar Ravinesh Ruchi Goel Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence Oman Journal of Ophthalmology cyclosporine interferon limbal conjunctival autograft pterygium |
| title | Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence |
| title_full | Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence |
| title_fullStr | Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence |
| title_full_unstemmed | Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence |
| title_short | Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence |
| title_sort | topical cyclosporine a and interferon alpha 2b as adjuvants to surgery to decrease pterygium recurrence |
| topic | cyclosporine interferon limbal conjunctival autograft pterygium |
| url | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=1;spage=30;epage=34;aulast=Raina |
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