Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin
BackgroundAcute thrombus in atrial septal defect occluders is a rare complication that requires aggressive, effective, and safe management. Tirofiban, a platelet glycoprotein IIb/IIIa receptor antagonist, is widely used for the management of thromboembolic diseases, such as coronary heart disease an...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1138717/full |
| _version_ | 1797884410693943296 |
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| author | Hui Wang Zhiwei Zhu Zhenyu Liu Yonghua Yuan Xuan Xu Liping Liu Jie Wen Xiaohui Xia Yu Zhang Jin He |
| author_facet | Hui Wang Zhiwei Zhu Zhenyu Liu Yonghua Yuan Xuan Xu Liping Liu Jie Wen Xiaohui Xia Yu Zhang Jin He |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | BackgroundAcute thrombus in atrial septal defect occluders is a rare complication that requires aggressive, effective, and safe management. Tirofiban, a platelet glycoprotein IIb/IIIa receptor antagonist, is widely used for the management of thromboembolic diseases, such as coronary heart disease and stroke. To date, there is no report using the GPIIb/IIIa receptor antagonist tirofiban for the management of ASD closure-related thrombosis in children.Case presentationHerein, we reported a case of a 5-year-old girl with ASD who presented with acute thrombus on the left disc of the occluder device immediately after transcatheter closure of ASD. The thrombus was successfully dissolved 24 h after a combined infusion of heparin and tirofiban, followed by 1 months of aspirin and clopidogrel and 5 months of aspirin alone. No thromboembolism or hemorrhage events occurred during follow-up for more than 2 years.ConclusionThe continuous infusion of GPIIb/IIIa receptor antagonist tirofiban combined with heparin may have beneficial effects for the management of thrombosis during ASD closure procedure. |
| first_indexed | 2024-04-10T04:07:13Z |
| format | Article |
| id | doaj.art-6a0d54a252b5499cbb210c3f2d125445 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T04:07:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6a0d54a252b5499cbb210c3f2d1254452023-03-13T04:44:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11387171138717Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparinHui Wang0Zhiwei Zhu1Zhenyu Liu2Yonghua Yuan3Xuan Xu4Liping Liu5Jie Wen6Xiaohui Xia7Yu Zhang8Jin He9Department of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Ultrasound, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Cardiology, Children’s Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaBackgroundAcute thrombus in atrial septal defect occluders is a rare complication that requires aggressive, effective, and safe management. Tirofiban, a platelet glycoprotein IIb/IIIa receptor antagonist, is widely used for the management of thromboembolic diseases, such as coronary heart disease and stroke. To date, there is no report using the GPIIb/IIIa receptor antagonist tirofiban for the management of ASD closure-related thrombosis in children.Case presentationHerein, we reported a case of a 5-year-old girl with ASD who presented with acute thrombus on the left disc of the occluder device immediately after transcatheter closure of ASD. The thrombus was successfully dissolved 24 h after a combined infusion of heparin and tirofiban, followed by 1 months of aspirin and clopidogrel and 5 months of aspirin alone. No thromboembolism or hemorrhage events occurred during follow-up for more than 2 years.ConclusionThe continuous infusion of GPIIb/IIIa receptor antagonist tirofiban combined with heparin may have beneficial effects for the management of thrombosis during ASD closure procedure.https://www.frontiersin.org/articles/10.3389/fped.2023.1138717/fullASDthrombosiscomplicationstirofibanchildrencase report |
| spellingShingle | Hui Wang Zhiwei Zhu Zhenyu Liu Yonghua Yuan Xuan Xu Liping Liu Jie Wen Xiaohui Xia Yu Zhang Jin He Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin Frontiers in Pediatrics ASD thrombosis complications tirofiban children case report |
| title | Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin |
| title_full | Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin |
| title_fullStr | Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin |
| title_full_unstemmed | Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin |
| title_short | Case report: Early thrombosis in left atrial during transcatheter closure of ASD in a child with favorable outcome after use of GPIIb/IIIa receptor antagonist and heparin |
| title_sort | case report early thrombosis in left atrial during transcatheter closure of asd in a child with favorable outcome after use of gpiib iiia receptor antagonist and heparin |
| topic | ASD thrombosis complications tirofiban children case report |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1138717/full |
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