Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients
Abstract Background Axillary lymph node involvement is one important prognostic factor in breast cancer, but the way to access this information has been modified over the years. This study evaluated if axillary ultrasound (US) coupled with fine-needle aspiration cytology (FNAC) can accurately predic...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-021-02391-3 |
| _version_ | 1819151558150979584 |
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| author | Isabela Panzeri Carlotti Buzatto Francisco José Cândido dos Reis Jurandyr Moreira de Andrade Tamara Cristina Gomes Ferraz Rodrigues Jéssica Maria Camargo Borba Amanda Homse Netto Marina Sconzo Polydoro Daniel Guimarães Tiezzi |
| author_facet | Isabela Panzeri Carlotti Buzatto Francisco José Cândido dos Reis Jurandyr Moreira de Andrade Tamara Cristina Gomes Ferraz Rodrigues Jéssica Maria Camargo Borba Amanda Homse Netto Marina Sconzo Polydoro Daniel Guimarães Tiezzi |
| author_sort | Isabela Panzeri Carlotti Buzatto |
| collection | DOAJ |
| description | Abstract Background Axillary lymph node involvement is one important prognostic factor in breast cancer, but the way to access this information has been modified over the years. This study evaluated if axillary ultrasound (US) coupled with fine-needle aspiration cytology (FNAC) can accurately predict clinically relevant node metastasis in patients with breast cancer, and thus assist clinical decisions Methods This is a cross-sectional study with retrospective data collection of 241 individuals (239 women and 2 men) with unilateral operable breast cancer who were submitted to preoperative axillary assessment by physical exam, US and FNAC if suspicious nodes by imaging. We calculated sensitivity, specificity, and accuracy of the methods. We compared the patient's characteristics using chi-square test, parametrics and non-parametrics statistics according to the variable. Results The most sensible method was US (0.59; 95% CI, 0.50–0.69), and the most specific was US coupled with FNAC (0.97; 95% CI, 0.92–0.99). Only 2.7% of the patients with normal axillary US had more than 2 metastatic nodes in the axillary lymph node dissection, against 50% of the patients with suspicious lymph nodes in the US and positive FNAC. Conclusions Axillary US coupled with FNAC can sort patients who have a few metastatic nodes at most from those with heavy axillary burden and could be one more tool to initially evaluate patients and define treatment strategies. |
| first_indexed | 2024-12-22T14:35:18Z |
| format | Article |
| id | doaj.art-6a11292be26b46fd8e3476cc6d521c40 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-22T14:35:18Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-6a11292be26b46fd8e3476cc6d521c402022-12-21T18:22:39ZengBMCWorld Journal of Surgical Oncology1477-78192021-09-011911810.1186/s12957-021-02391-3Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patientsIsabela Panzeri Carlotti Buzatto0Francisco José Cândido dos Reis1Jurandyr Moreira de Andrade2Tamara Cristina Gomes Ferraz Rodrigues3Jéssica Maria Camargo Borba4Amanda Homse Netto5Marina Sconzo Polydoro6Daniel Guimarães Tiezzi7Department of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloDepartment of Gynecology and Obstetrics, Breast Disease Division, Ribeirão Preto Medical School, University of São PauloAbstract Background Axillary lymph node involvement is one important prognostic factor in breast cancer, but the way to access this information has been modified over the years. This study evaluated if axillary ultrasound (US) coupled with fine-needle aspiration cytology (FNAC) can accurately predict clinically relevant node metastasis in patients with breast cancer, and thus assist clinical decisions Methods This is a cross-sectional study with retrospective data collection of 241 individuals (239 women and 2 men) with unilateral operable breast cancer who were submitted to preoperative axillary assessment by physical exam, US and FNAC if suspicious nodes by imaging. We calculated sensitivity, specificity, and accuracy of the methods. We compared the patient's characteristics using chi-square test, parametrics and non-parametrics statistics according to the variable. Results The most sensible method was US (0.59; 95% CI, 0.50–0.69), and the most specific was US coupled with FNAC (0.97; 95% CI, 0.92–0.99). Only 2.7% of the patients with normal axillary US had more than 2 metastatic nodes in the axillary lymph node dissection, against 50% of the patients with suspicious lymph nodes in the US and positive FNAC. Conclusions Axillary US coupled with FNAC can sort patients who have a few metastatic nodes at most from those with heavy axillary burden and could be one more tool to initially evaluate patients and define treatment strategies.https://doi.org/10.1186/s12957-021-02391-3Breast cancerLymph node metastasisAxillary ultrasoundFine-needle aspiration cytology |
| spellingShingle | Isabela Panzeri Carlotti Buzatto Francisco José Cândido dos Reis Jurandyr Moreira de Andrade Tamara Cristina Gomes Ferraz Rodrigues Jéssica Maria Camargo Borba Amanda Homse Netto Marina Sconzo Polydoro Daniel Guimarães Tiezzi Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients World Journal of Surgical Oncology Breast cancer Lymph node metastasis Axillary ultrasound Fine-needle aspiration cytology |
| title | Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| title_full | Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| title_fullStr | Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| title_full_unstemmed | Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| title_short | Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| title_sort | axillary ultrasound and fine needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients |
| topic | Breast cancer Lymph node metastasis Axillary ultrasound Fine-needle aspiration cytology |
| url | https://doi.org/10.1186/s12957-021-02391-3 |
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