PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels

PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels

Summary: Loss-of-function mutations in proline-rich transmembrane protein-2 (PRRT2) cause paroxysmal disorders associated with defective Ca2+ dependence of glutamatergic transmission. We find that either acute or constitutive PRRT2 deletion induces a significant decrease in the amplitude of evoked e...

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Bibliographic Details
Main Authors: Daniele Ferrante, Bruno Sterlini, Cosimo Prestigio, Antonella Marte, Anna Corradi, Franco Onofri, Giorgio Tortarolo, Giuseppe Vicidomini, Andrea Petretto, Jessica Muià, Agnes Thalhammer, Pierluigi Valente, Lorenzo A. Cingolani, Fabio Benfenati, Pietro Baldelli
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
excitatory synaptic transmission
synchronous neurotransmitter release
SNARE complex
voltage-gated Ca2+ channels
P/Q-type Ca2+ channels
channel trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006136

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