Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak
Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion. A decrease in CBF results in brain edema which triggers damage to neuron ce...
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| Format: | Article |
| Language: | English |
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Fakultas Kedokteran Universitas Andalas
2022-05-01
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| Series: | Jurnal Ilmu Kesehatan Indonesia |
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| Online Access: | http://jikesi.fk.unand.ac.id/index.php/jikesi/article/view/318 |
| _version_ | 1797817155995041792 |
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| author | Muhammad Arief Ansyar Nita Afriani Aisyah Ellyanti |
| author_facet | Muhammad Arief Ansyar Nita Afriani Aisyah Ellyanti |
| author_sort | Muhammad Arief Ansyar |
| collection | DOAJ |
| description | Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion. A decrease in CBF results in brain edema which triggers damage to neuron cells. This study uses isoproterenol to induce brain edema. This damage is prevented by giving ramipril with the aim of improving cardiac and brain perfusion.
Objective. To see the effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol.
Methods. This research is an experimental study which was used 21 experimental animals which were divided into 3 groups (K-, K +, and P). The treatment group (P) was given ramipril at a dose of 3 mg/KgBW for 7 days. On the 8th and 9th day K+ and P groups were injected by isoproterenol 85 mg/KgBW to induce brain edema through AMI. Data analysis was performed using the Kruskal-Wallis Test and Mann Whitney U Test (MWUT).
Results. The average number of neuron cell damage in the K -, K +, and P group, respectively, 6.2, 26.3 and 17.33. Significant differences were obtained for each group with a value of p = 0.001 (p <0.05).
Conclusion. There is a significant effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol. |
| first_indexed | 2024-03-13T08:48:05Z |
| format | Article |
| id | doaj.art-6a151128558e443daa5dbf801b402253 |
| institution | Directory Open Access Journal |
| issn | 2722-4848 |
| language | English |
| last_indexed | 2024-03-13T08:48:05Z |
| publishDate | 2022-05-01 |
| publisher | Fakultas Kedokteran Universitas Andalas |
| record_format | Article |
| series | Jurnal Ilmu Kesehatan Indonesia |
| spelling | doaj.art-6a151128558e443daa5dbf801b4022532023-05-29T22:13:17ZengFakultas Kedokteran Universitas AndalasJurnal Ilmu Kesehatan Indonesia2722-48482022-05-012291610.25077/jikesi.v2i2.318318Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema OtakMuhammad Arief Ansyar0Nita Afriani1Aisyah Ellyanti2Univertas AndalasFakultas Kedokteran Universitas AndalasFakultas Kedokteran Universitas AndalasBackground. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion. A decrease in CBF results in brain edema which triggers damage to neuron cells. This study uses isoproterenol to induce brain edema. This damage is prevented by giving ramipril with the aim of improving cardiac and brain perfusion. Objective. To see the effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol. Methods. This research is an experimental study which was used 21 experimental animals which were divided into 3 groups (K-, K +, and P). The treatment group (P) was given ramipril at a dose of 3 mg/KgBW for 7 days. On the 8th and 9th day K+ and P groups were injected by isoproterenol 85 mg/KgBW to induce brain edema through AMI. Data analysis was performed using the Kruskal-Wallis Test and Mann Whitney U Test (MWUT). Results. The average number of neuron cell damage in the K -, K +, and P group, respectively, 6.2, 26.3 and 17.33. Significant differences were obtained for each group with a value of p = 0.001 (p <0.05). Conclusion. There is a significant effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol.http://jikesi.fk.unand.ac.id/index.php/jikesi/article/view/318isoproterenolramiprilneuron cellsbrain edema |
| spellingShingle | Muhammad Arief Ansyar Nita Afriani Aisyah Ellyanti Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak Jurnal Ilmu Kesehatan Indonesia isoproterenol ramipril neuron cells brain edema |
| title | Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak |
| title_full | Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak |
| title_fullStr | Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak |
| title_full_unstemmed | Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak |
| title_short | Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak |
| title_sort | pengaruh ramipril terhadap gambaran mikroskopis sel neuron otak tikus wistar yang mengalami edema otak |
| topic | isoproterenol ramipril neuron cells brain edema |
| url | http://jikesi.fk.unand.ac.id/index.php/jikesi/article/view/318 |
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