Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

<p>Abstract</p> <p>Background</p> <p>In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce...

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Bibliographic Details
Main Authors: Simonson Michael S, Mishra Rangnath
Format: Article
Language:English
Published: BMC 2005-01-01
Series:Cardiovascular Diabetology
Subjects:
free fatty acids
microvascular
apoptosis
caspase 9
lipotoxicity
mesangial cells
Online Access:http://www.cardiab.com/content/4/1/2

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