Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France
The impact of sex on the outcomes of patients with cardiovascular disease is still incompletely understood. The aim of this nationwide multicenter observational study was to investigate the impact of sex on post-operative outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR) fo...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/8/2253 |
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| author | Fabien Lareyre Juliette Raffort Christian-Alexander Behrendt Arindam Chaudhuri Cong Duy Lê Roxane Fabre Christian Pradier Laurent Bailly |
| author_facet | Fabien Lareyre Juliette Raffort Christian-Alexander Behrendt Arindam Chaudhuri Cong Duy Lê Roxane Fabre Christian Pradier Laurent Bailly |
| author_sort | Fabien Lareyre |
| collection | DOAJ |
| description | The impact of sex on the outcomes of patients with cardiovascular disease is still incompletely understood. The aim of this nationwide multicenter observational study was to investigate the impact of sex on post-operative outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR) for intact thoracic aortic aneurysm (iTAA). The French National Health Insurance Information System was searched to identify these patients over a ten-year retrospective period. Post-operative outcomes, 30-day and overall mortality were recorded. Among the 7383 patients included (5521 men and 1862 women), females were significantly older than males (66.8 vs. 64.8 years, <i>p</i> < 0.001). They were less frequently diagnosed with cardiovascular comorbidities. Post-operatively, women had less frequently respiratory (10.9 vs. 13.7%, <i>p</i> = 0.002) as well as cardiac complications (34.3 vs. 37.3%, <i>p</i> = 0.023), but they had more frequently arterial complications (52.8 vs. 49.8%, <i>p</i> = 0.024). There was no significant difference on overall mortality for a mean follow-up of 2.2 years (26.9 vs. 27.6%, <i>p</i> = 0.58). In the multivariable regression model, female sex was not associated with 30-day or overall mortality. Although women had a favorable comorbidity profile, the short-term and long-term survival was similar. The significantly higher rate of arterial complications suggests that women may be at higher risk of access-vessel-related complications. |
| first_indexed | 2024-03-09T13:29:14Z |
| format | Article |
| id | doaj.art-6a1ab7f0b4064bc6aace5d5da207a665 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:29:14Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6a1ab7f0b4064bc6aace5d5da207a6652023-11-30T21:20:08ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118225310.3390/jcm11082253Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in FranceFabien Lareyre0Juliette Raffort1Christian-Alexander Behrendt2Arindam Chaudhuri3Cong Duy Lê4Roxane Fabre5Christian Pradier6Laurent Bailly7Department of Vascular Surgery, Hospital of Antibes Juan-les-Pins, 06600 Antibes, FranceUniversité Côte d’Azur, Inserm U1065, C3M, 06204 Nice, FranceResearch Group GermanVasc, Department of Vascular Medicine, University Heart and Vascular Centre UKE Hamburg, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, GermanyBedfordshire-Milton Keynes Vascular Centre, Bedfordshire Hospitals NHS Foundation Trust, Bedford MK42 9DJ, UKDepartment of Vascular Surgery, Hospital of Antibes Juan-les-Pins, 06600 Antibes, FranceCoBTeK Lab, Université Côte d’Azur, 06001 Nice, FrancePublic Health Department, University Hospital of Nice, Université Côte d’Azur, 06001 Nice, FrancePublic Health Department, University Hospital of Nice, Université Côte d’Azur, 06001 Nice, FranceThe impact of sex on the outcomes of patients with cardiovascular disease is still incompletely understood. The aim of this nationwide multicenter observational study was to investigate the impact of sex on post-operative outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR) for intact thoracic aortic aneurysm (iTAA). The French National Health Insurance Information System was searched to identify these patients over a ten-year retrospective period. Post-operative outcomes, 30-day and overall mortality were recorded. Among the 7383 patients included (5521 men and 1862 women), females were significantly older than males (66.8 vs. 64.8 years, <i>p</i> < 0.001). They were less frequently diagnosed with cardiovascular comorbidities. Post-operatively, women had less frequently respiratory (10.9 vs. 13.7%, <i>p</i> = 0.002) as well as cardiac complications (34.3 vs. 37.3%, <i>p</i> = 0.023), but they had more frequently arterial complications (52.8 vs. 49.8%, <i>p</i> = 0.024). There was no significant difference on overall mortality for a mean follow-up of 2.2 years (26.9 vs. 27.6%, <i>p</i> = 0.58). In the multivariable regression model, female sex was not associated with 30-day or overall mortality. Although women had a favorable comorbidity profile, the short-term and long-term survival was similar. The significantly higher rate of arterial complications suggests that women may be at higher risk of access-vessel-related complications.https://www.mdpi.com/2077-0383/11/8/2253thoracic aortic aneurysmthoracic endovascular repairTEVARoutcomesnationwide studysex |
| spellingShingle | Fabien Lareyre Juliette Raffort Christian-Alexander Behrendt Arindam Chaudhuri Cong Duy Lê Roxane Fabre Christian Pradier Laurent Bailly Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France Journal of Clinical Medicine thoracic aortic aneurysm thoracic endovascular repair TEVAR outcomes nationwide study sex |
| title | Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France |
| title_full | Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France |
| title_fullStr | Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France |
| title_full_unstemmed | Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France |
| title_short | Impact of Female Sex on Outcomes of Patients Undergoing Thoracic Endovascular Aortic Aneurysm Repair: A Ten-Year Retrospective Nationwide Study in France |
| title_sort | impact of female sex on outcomes of patients undergoing thoracic endovascular aortic aneurysm repair a ten year retrospective nationwide study in france |
| topic | thoracic aortic aneurysm thoracic endovascular repair TEVAR outcomes nationwide study sex |
| url | https://www.mdpi.com/2077-0383/11/8/2253 |
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