Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri]
The content of synthetic cannabinoids (SC) which are known in Europe as Spice, in the U.S.A. as K2, and in Turkey as Bonsai or Jamaica is not standard. Also SC are known to contain approximately 400 chemical compounds which vary from country to country. SC mimics the effect of Δ9-tetrahydro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2016-12-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=217762 |
| _version_ | 1797329227706531840 |
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| author | Hakan Parlakpinar Osman Celbis Onural Ozhan Semih Petekkaya Emine Samdanci Necip Ermis Pelin Koparir Ozcan Soylu Ahmet Acet |
| author_facet | Hakan Parlakpinar Osman Celbis Onural Ozhan Semih Petekkaya Emine Samdanci Necip Ermis Pelin Koparir Ozcan Soylu Ahmet Acet |
| author_sort | Hakan Parlakpinar |
| collection | DOAJ |
| description | The content of synthetic cannabinoids (SC) which are known in Europe as Spice, in the U.S.A. as K2, and in Turkey as Bonsai or Jamaica is not standard. Also SC are known to contain approximately 400 chemical compounds which vary from country to country. SC mimics the effect of Δ9-tetrahydrocannabinol (THC) which is the major effective content of Cannabis or Marijuana by cannabinoid-1 (CB1) and cannabinoid-2 (CB2) receptors in the body cell. Although the new SC are synthesized and the number of new variants is increased in every day; JWH-018 among these variants exerts full agonist effect on both CB1 and CB2 receptors also it has a short-term effect as 2 hours. For this reason, JWH-018 is the most commonly used as SC. There are a few data in the literature regarding to the pharmacokinetic and pharmacodynamic effects of SC. Furthermore, most of the existing data are based on in vitro experiments. In the JWH-018 report, at Critical Review Report Agenda item 4.5 Expert Committee on Drug Dependence of World Health Organization (WHO), Thirty‐sixth Meeting Geneva, 16‐20 June 2014, is declared that despite a marked elevation of the heart rate is one of the clinical signs very often seen after intoxication with SC, there is no available study data regarding effects of SC on cardiovascular, respiratory, gastrointestinal, liver, kidneys and genitourinary systems. The aim of this review is to highlight cardiovascular effects of JW-018 which is considered to be the prototype for synthetic cannabinoids to prepare the ground for new work to be done. [Med-Science 2016; 5(4.000): 1049-54] |
| first_indexed | 2024-03-08T07:01:45Z |
| format | Article |
| id | doaj.art-6a1ae970bef3405281bf5ee352bc1a25 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T07:01:45Z |
| publishDate | 2016-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-6a1ae970bef3405281bf5ee352bc1a252024-02-03T05:37:10ZengSociety of Turaz BilimMedicine Science2147-06342016-12-015410495410.5455/medscience.2016.05.8452217762Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri]Hakan Parlakpinar0Osman Celbis1Onural Ozhan2Semih Petekkaya3Emine Samdanci4Necip Ermis5Pelin Koparir6Ozcan Soylu7Ahmet Acet8Inonu Universitesi Tip Fakultesi Tibbi Farmakoloji Anabilim Dali, Malatya, Turkiye. Inonu Universitesi Tip Fakultesi Adli Tip Anabilim Dali, Malatya, Turkiye. Inonu Universitesi Tip Fakultesi Tibbi Farmakoloji Anabilim Dali, Malatya, Turkiye. T.C. Adalet Bakanligi Adli Tip Kurumu Malatya Grup Baskanligi, Malatya, Turkiye. Inonu Universitesi Tip Fakultesi Tibbi Patoloji Anabilim Dali, Malatya, Turkiye. Inonu Universitesi Tip Fakultesi Kardiyoloji Anabilim Dali, Malatya, Turkiye. T.C. Adalet Bakanligi Adli Tip Kurumu Malatya Grup Baskanligi, Malatya, Turkiye. T.C. Adalet Bakanligi Adli Tip Kurumu Malatya Grup Baskanligi, Malatya, Turkiye. Inonu Universitesi Tip Fakultesi Tibbi Farmakoloji Anabilim Dali, Malatya, Turkiye.The content of synthetic cannabinoids (SC) which are known in Europe as Spice, in the U.S.A. as K2, and in Turkey as Bonsai or Jamaica is not standard. Also SC are known to contain approximately 400 chemical compounds which vary from country to country. SC mimics the effect of Δ9-tetrahydrocannabinol (THC) which is the major effective content of Cannabis or Marijuana by cannabinoid-1 (CB1) and cannabinoid-2 (CB2) receptors in the body cell. Although the new SC are synthesized and the number of new variants is increased in every day; JWH-018 among these variants exerts full agonist effect on both CB1 and CB2 receptors also it has a short-term effect as 2 hours. For this reason, JWH-018 is the most commonly used as SC. There are a few data in the literature regarding to the pharmacokinetic and pharmacodynamic effects of SC. Furthermore, most of the existing data are based on in vitro experiments. In the JWH-018 report, at Critical Review Report Agenda item 4.5 Expert Committee on Drug Dependence of World Health Organization (WHO), Thirty‐sixth Meeting Geneva, 16‐20 June 2014, is declared that despite a marked elevation of the heart rate is one of the clinical signs very often seen after intoxication with SC, there is no available study data regarding effects of SC on cardiovascular, respiratory, gastrointestinal, liver, kidneys and genitourinary systems. The aim of this review is to highlight cardiovascular effects of JW-018 which is considered to be the prototype for synthetic cannabinoids to prepare the ground for new work to be done. [Med-Science 2016; 5(4.000): 1049-54]http://www.ejmanager.com/fulltextpdf.php?mno=217762synthetic cannabinoidsbonsaijwh-018heartvessel |
| spellingShingle | Hakan Parlakpinar Osman Celbis Onural Ozhan Semih Petekkaya Emine Samdanci Necip Ermis Pelin Koparir Ozcan Soylu Ahmet Acet Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] Medicine Science synthetic cannabinoids bonsai jwh-018 heart vessel |
| title | Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] |
| title_full | Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] |
| title_fullStr | Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] |
| title_full_unstemmed | Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] |
| title_short | Cardiovascular effects of JWH-018 from synthetic cannabinoids [Sentetik kannabinoidlerden JWH-018in kardiyovaskuler etkileri] |
| title_sort | cardiovascular effects of jwh 018 from synthetic cannabinoids sentetik kannabinoidlerden jwh 018in kardiyovaskuler etkileri |
| topic | synthetic cannabinoids bonsai jwh-018 heart vessel |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=217762 |
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