Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis
Objectives: Due to the inflammatory nature of multiple sclerosis (MS), the most widely used therapeutic approach targets the immune response but can comprise side effects (e.g. secondary immunosuppression). For these reasons, among non-pharmaceutical interventions without known side effects, physica...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229924000281 |
| _version_ | 1797208856324997120 |
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| author | V. Bellisario G. Squillacioti F. Ghelli MC. Monti L. Correale C. Montomoli R. Bono |
| author_facet | V. Bellisario G. Squillacioti F. Ghelli MC. Monti L. Correale C. Montomoli R. Bono |
| author_sort | V. Bellisario |
| collection | DOAJ |
| description | Objectives: Due to the inflammatory nature of multiple sclerosis (MS), the most widely used therapeutic approach targets the immune response but can comprise side effects (e.g. secondary immunosuppression). For these reasons, among non-pharmaceutical interventions without known side effects, physical activity (PA) gained importance because it is feasible, safe and a supportive complementary treatment strategy to alleviate symptoms in MS subjects. Consequently, the main aim of this systematic review is to analyze the effect of PA protocols, as a complementary therapy, on inflammatory status in MS patients. Methods: Four electronic databases (PubMed, Embase, CINAHL, and Cochrane CENTRAL) were systematically searched up to 01 June 2023 (Prospero Protocol ID=CRD42021244418). The refined search strategy was based on three concepts: “MULTIPLE SCLEROSIS” AND “PHYSICAL ACTIVITY” AND “INFLAMMATION”. Results: three main findings emerged: 1) untrained subjects showed a negative modulation of inflammatory biomarkers concentrations when compared to trained people (−0.74, 95 %C.I.–1.16, −0.32); 2) training modulated positively inflammatory biomarkers (+0.47, 95 %C.I. 0.24,0.71); 3) Aerobic PA protocol enhance higher positive influence on inflammation. Conclusions: Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation. |
| first_indexed | 2024-04-24T09:45:27Z |
| format | Article |
| id | doaj.art-6a1bef53e4d84540b171c8941e1e5167 |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-04-24T09:45:27Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-6a1bef53e4d84540b171c8941e1e51672024-04-15T04:05:34ZengElsevierComplementary Therapies in Medicine0965-22992024-06-0182103040Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysisV. Bellisario0G. Squillacioti1F. Ghelli2MC. Monti3L. Correale4C. Montomoli5R. Bono6Department of Public Health and Pediatrics, University of Turin, Turin, ItalyDepartment of Public Health and Pediatrics, University of Turin, Turin, Italy; Correspondence to: Department of Public Health and Pediatrics, Italy.Department of Public Health and Pediatrics, University of Turin, Turin, ItalyDepartment of Public Health Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, ItalyDepartment of Public Health Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, ItalyDepartment of Public Health Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, ItalyDepartment of Public Health and Pediatrics, University of Turin, Turin, ItalyObjectives: Due to the inflammatory nature of multiple sclerosis (MS), the most widely used therapeutic approach targets the immune response but can comprise side effects (e.g. secondary immunosuppression). For these reasons, among non-pharmaceutical interventions without known side effects, physical activity (PA) gained importance because it is feasible, safe and a supportive complementary treatment strategy to alleviate symptoms in MS subjects. Consequently, the main aim of this systematic review is to analyze the effect of PA protocols, as a complementary therapy, on inflammatory status in MS patients. Methods: Four electronic databases (PubMed, Embase, CINAHL, and Cochrane CENTRAL) were systematically searched up to 01 June 2023 (Prospero Protocol ID=CRD42021244418). The refined search strategy was based on three concepts: “MULTIPLE SCLEROSIS” AND “PHYSICAL ACTIVITY” AND “INFLAMMATION”. Results: three main findings emerged: 1) untrained subjects showed a negative modulation of inflammatory biomarkers concentrations when compared to trained people (−0.74, 95 %C.I.–1.16, −0.32); 2) training modulated positively inflammatory biomarkers (+0.47, 95 %C.I. 0.24,0.71); 3) Aerobic PA protocol enhance higher positive influence on inflammation. Conclusions: Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation.http://www.sciencedirect.com/science/article/pii/S0965229924000281InflammationMultiple sclerosisPhysical activityComplementary therapiesTertiary prevention |
| spellingShingle | V. Bellisario G. Squillacioti F. Ghelli MC. Monti L. Correale C. Montomoli R. Bono Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis Complementary Therapies in Medicine Inflammation Multiple sclerosis Physical activity Complementary therapies Tertiary prevention |
| title | Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis |
| title_full | Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis |
| title_fullStr | Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis |
| title_full_unstemmed | Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis |
| title_short | Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis |
| title_sort | inflammation and physical activity in multiple sclerosis patients a systematic review and meta analysis |
| topic | Inflammation Multiple sclerosis Physical activity Complementary therapies Tertiary prevention |
| url | http://www.sciencedirect.com/science/article/pii/S0965229924000281 |
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