The Role of Efferocytosis in Autoimmune Diseases
Apoptosis happens continuously for millions of cells along with the active removal of apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of “find me,” “eat me,” and “tolera...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01645/full |
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| author | Fereshte Abdolmaleki Najmeh Farahani Seyed Mohammad Gheibi Hayat Matteo Pirro Vanessa Bianconi George E. Barreto George E. Barreto Amirhossein Sahebkar Amirhossein Sahebkar Amirhossein Sahebkar |
| author_facet | Fereshte Abdolmaleki Najmeh Farahani Seyed Mohammad Gheibi Hayat Matteo Pirro Vanessa Bianconi George E. Barreto George E. Barreto Amirhossein Sahebkar Amirhossein Sahebkar Amirhossein Sahebkar |
| author_sort | Fereshte Abdolmaleki |
| collection | DOAJ |
| description | Apoptosis happens continuously for millions of cells along with the active removal of apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of “find me,” “eat me,” and “tolerate me” signals facilitating the engulfment of dying cells through phagocytosis by macrophages and dendritic cells. The clearance of dead cells via phagocytes is of utmost importance to maintain the immune system tolerance to self-antigens. Accordingly, this biological activity prevents the release of autoantigens by dead cells, thus potentially suppressing the undesirable autoreactivity of immune cells and the appearance of inflammatory autoimmune disorders as systemic lupus erythematous and rheumatoid arthritis. In the present study, the apoptosis pathways and their immune regulation were reviewed. Moreover, efferocytosis process and its impairment in association with some autoimmune diseases were discussed. |
| first_indexed | 2024-12-10T03:37:34Z |
| format | Article |
| id | doaj.art-6a1e103224d5406abacd535f1c25dbea |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T03:37:34Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6a1e103224d5406abacd535f1c25dbea2022-12-22T02:03:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01645381815The Role of Efferocytosis in Autoimmune DiseasesFereshte Abdolmaleki0Najmeh Farahani1Seyed Mohammad Gheibi Hayat2Matteo Pirro3Vanessa Bianconi4George E. Barreto5George E. Barreto6Amirhossein Sahebkar7Amirhossein Sahebkar8Amirhossein Sahebkar9Cellular and Molecular Research Center, School of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, IranDepartment of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranUnit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, ItalyUnit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, ItalyDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, ColombiaInstituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, ChileBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranNeurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, IranSchool of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranApoptosis happens continuously for millions of cells along with the active removal of apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of “find me,” “eat me,” and “tolerate me” signals facilitating the engulfment of dying cells through phagocytosis by macrophages and dendritic cells. The clearance of dead cells via phagocytes is of utmost importance to maintain the immune system tolerance to self-antigens. Accordingly, this biological activity prevents the release of autoantigens by dead cells, thus potentially suppressing the undesirable autoreactivity of immune cells and the appearance of inflammatory autoimmune disorders as systemic lupus erythematous and rheumatoid arthritis. In the present study, the apoptosis pathways and their immune regulation were reviewed. Moreover, efferocytosis process and its impairment in association with some autoimmune diseases were discussed.https://www.frontiersin.org/article/10.3389/fimmu.2018.01645/fullapoptosisefferocytosisautoimmune diseasephagocytosissystemic lupus erythematous |
| spellingShingle | Fereshte Abdolmaleki Najmeh Farahani Seyed Mohammad Gheibi Hayat Matteo Pirro Vanessa Bianconi George E. Barreto George E. Barreto Amirhossein Sahebkar Amirhossein Sahebkar Amirhossein Sahebkar The Role of Efferocytosis in Autoimmune Diseases Frontiers in Immunology apoptosis efferocytosis autoimmune disease phagocytosis systemic lupus erythematous |
| title | The Role of Efferocytosis in Autoimmune Diseases |
| title_full | The Role of Efferocytosis in Autoimmune Diseases |
| title_fullStr | The Role of Efferocytosis in Autoimmune Diseases |
| title_full_unstemmed | The Role of Efferocytosis in Autoimmune Diseases |
| title_short | The Role of Efferocytosis in Autoimmune Diseases |
| title_sort | role of efferocytosis in autoimmune diseases |
| topic | apoptosis efferocytosis autoimmune disease phagocytosis systemic lupus erythematous |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01645/full |
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