Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats
This study was conducted to investigate the effects of branched chain amino acids (BCAAs) consumption on myocardium and coronary arteries, in rats subjected to regular and intense exercise. Eight-week old, 30 male rats were randomly divided into experimental- and controlgroups. For a total of 8 week...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2018-03-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2344 |
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| author | İbrahim RENCÜZOĞULLARI Yavuz KARABAĞ Metin ÇAĞDAŞ Yasemen ADALI Süleyman KARAKOYUN Ekin Emre ERKILIÇ Mahmut YESİN Fatih MEDETALİBEYOĞLU İnanç ARTAÇ Doğan İLİŞ Uğur AYDIN |
| author_facet | İbrahim RENCÜZOĞULLARI Yavuz KARABAĞ Metin ÇAĞDAŞ Yasemen ADALI Süleyman KARAKOYUN Ekin Emre ERKILIÇ Mahmut YESİN Fatih MEDETALİBEYOĞLU İnanç ARTAÇ Doğan İLİŞ Uğur AYDIN |
| author_sort | İbrahim RENCÜZOĞULLARI |
| collection | DOAJ |
| description | This study was conducted to investigate the effects of branched chain amino acids (BCAAs) consumption on myocardium and coronary
arteries, in rats subjected to regular and intense exercise. Eight-week old, 30 male rats were randomly divided into experimental- and controlgroups.
For a total of 8 weeks, every other day, both groups were subjected to a ladder-climbing exercise on a 1.5 m long ladder, with 2.5
cm steps interval, at 70 degrees angle. The experimental group, besides the standard diet, was additionally fed BCAA-supplement at a dose
of 1.5 mg/g/day. This study showed that, the experimental group had more frequent atherosclerotic lesions compared to the control group
(61.5% vs. 21.4%; p=0.034). Although creatine kinase was similar between the groups, creatine kinase - myocardial band isoform (CK-MB) was
significantly higher in the experimental group compared both to control and baseline levels. This is the first study that examines the effects
of consuming BCAA supplements on myocardium and coronary arteries in rats subjected to prolonged exercise. We demonstrated that
continuous and long-term consumption of BCAA supplement in endurance exercises was associated with coronary atherosclerotic process
and myocardial injury. |
| first_indexed | 2024-03-13T04:37:22Z |
| format | Article |
| id | doaj.art-6a1ee581ea014254977b2cd3fa686249 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:37:22Z |
| publishDate | 2018-03-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-6a1ee581ea014254977b2cd3fa6862492023-06-19T06:43:43ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512018-03-0124345946610.9775/kvfd.2017.192202344Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising ratsİbrahim RENCÜZOĞULLARI0Yavuz KARABAĞ1Metin ÇAĞDAŞ2Yasemen ADALI3Süleyman KARAKOYUN4Ekin Emre ERKILIÇ5Mahmut YESİN6Fatih MEDETALİBEYOĞLU7İnanç ARTAÇ8Doğan İLİŞ9Uğur AYDIN10Kafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Pathology, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Veterinary Faculty, Department of Internal Medicine, TR-36100 Kars - TURKEYKars Harakani State Hospital, Department of Cardiology, TR-36200 Kars - TURKEYKafkas University Engineering Faculty, Department of Mechanical Engineering, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Medical Faculty, Department of Cardiology, TR-36100 Kars - TURKEYKafkas University Veterinary Faculty, Department of Veterinary Surgery, TR-36100 Kars - TURKEYThis study was conducted to investigate the effects of branched chain amino acids (BCAAs) consumption on myocardium and coronary arteries, in rats subjected to regular and intense exercise. Eight-week old, 30 male rats were randomly divided into experimental- and controlgroups. For a total of 8 weeks, every other day, both groups were subjected to a ladder-climbing exercise on a 1.5 m long ladder, with 2.5 cm steps interval, at 70 degrees angle. The experimental group, besides the standard diet, was additionally fed BCAA-supplement at a dose of 1.5 mg/g/day. This study showed that, the experimental group had more frequent atherosclerotic lesions compared to the control group (61.5% vs. 21.4%; p=0.034). Although creatine kinase was similar between the groups, creatine kinase - myocardial band isoform (CK-MB) was significantly higher in the experimental group compared both to control and baseline levels. This is the first study that examines the effects of consuming BCAA supplements on myocardium and coronary arteries in rats subjected to prolonged exercise. We demonstrated that continuous and long-term consumption of BCAA supplement in endurance exercises was associated with coronary atherosclerotic process and myocardial injury.https://vetdergikafkas.org/pdf.php?id=2344branched chain amino acidsatherosclerosisendurance exercisesmyocardial injury |
| spellingShingle | İbrahim RENCÜZOĞULLARI Yavuz KARABAĞ Metin ÇAĞDAŞ Yasemen ADALI Süleyman KARAKOYUN Ekin Emre ERKILIÇ Mahmut YESİN Fatih MEDETALİBEYOĞLU İnanç ARTAÇ Doğan İLİŞ Uğur AYDIN Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats Kafkas Universitesi Veteriner Fakültesi Dergisi branched chain amino acids atherosclerosis endurance exercises myocardial injury |
| title | Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| title_full | Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| title_fullStr | Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| title_full_unstemmed | Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| title_short | Impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| title_sort | impact of supplementation with branched chain amino acids on myocardium and coronary in regularly and intensively exercising rats |
| topic | branched chain amino acids atherosclerosis endurance exercises myocardial injury |
| url | https://vetdergikafkas.org/pdf.php?id=2344 |
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