Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS), which is disabling and majorly involves younger population. Various available treatments in forms of immunomodulation are not very effective; however, stem cell transplantation seems to be promising in recent...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=4;spage=459;epage=463;aulast=Pandit |
| _version_ | 1818132245155676160 |
|---|---|
| author | Awadh Kishor Pandit Kameshwar Prasad Tulika Seth |
| author_facet | Awadh Kishor Pandit Kameshwar Prasad Tulika Seth |
| author_sort | Awadh Kishor Pandit |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS), which is disabling and majorly involves younger population. Various available treatments in forms of immunomodulation are not very effective; however, stem cell transplantation seems to be promising in recent literature. The current case report is a novel evidence for autologous hematopoietic stem cell transplantation (HSCT) in progressive MS. Case Summary: A 33 year old male with secondary progressive MS (SPMS), after being failed and/or intolerance to standard approved interferon (IFN) and mitoxantrone therapy, autologous HSCT was administered. At 2years of post-stem cell transplantation follow-up, he has remained stable with some improvement in functional status (Expanded Disability Status Scale (EDSS) reduced by 1.5), with no relapse, no treatment related complications, and no fresh magnetic resonance imaging (MRI) lesions. Conclusion: Autologous stem cell transplantation may be beneficial in progressive forms of MS, but needs to be tested in well-designed randomized trial. |
| first_indexed | 2024-12-11T08:33:46Z |
| format | Article |
| id | doaj.art-6a1f4613d1f64aab8112244712d56739 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-11T08:33:46Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-6a1f4613d1f64aab8112244712d567392022-12-22T01:14:24ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492015-01-0118445946310.4103/0972-2327.165482Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosisAwadh Kishor PanditKameshwar PrasadTulika SethMultiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS), which is disabling and majorly involves younger population. Various available treatments in forms of immunomodulation are not very effective; however, stem cell transplantation seems to be promising in recent literature. The current case report is a novel evidence for autologous hematopoietic stem cell transplantation (HSCT) in progressive MS. Case Summary: A 33 year old male with secondary progressive MS (SPMS), after being failed and/or intolerance to standard approved interferon (IFN) and mitoxantrone therapy, autologous HSCT was administered. At 2years of post-stem cell transplantation follow-up, he has remained stable with some improvement in functional status (Expanded Disability Status Scale (EDSS) reduced by 1.5), with no relapse, no treatment related complications, and no fresh magnetic resonance imaging (MRI) lesions. Conclusion: Autologous stem cell transplantation may be beneficial in progressive forms of MS, but needs to be tested in well-designed randomized trial.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=4;spage=459;epage=463;aulast=PanditAutologous hematopoietic stem cell transplantationHSCT in MSmultiple sclerosisstem cell transplantation |
| spellingShingle | Awadh Kishor Pandit Kameshwar Prasad Tulika Seth Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis Annals of Indian Academy of Neurology Autologous hematopoietic stem cell transplantation HSCT in MS multiple sclerosis stem cell transplantation |
| title | Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| title_full | Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| title_fullStr | Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| title_full_unstemmed | Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| title_short | Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| title_sort | autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis |
| topic | Autologous hematopoietic stem cell transplantation HSCT in MS multiple sclerosis stem cell transplantation |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=4;spage=459;epage=463;aulast=Pandit |
| work_keys_str_mv | AT awadhkishorpandit autologoushematopoieticstemcelltransplantationinprogressiveseveremultiplesclerosis AT kameshwarprasad autologoushematopoieticstemcelltransplantationinprogressiveseveremultiplesclerosis AT tulikaseth autologoushematopoieticstemcelltransplantationinprogressiveseveremultiplesclerosis |