Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity
Abstract Background The autonomic nervous system is linked to hyperdynamic circulation in cirrhosis and several studies have highlighted the crucial role that systemic inflammation elicits in altering sympathovagal equilibrium with the consequent reduction in heart rate variability (HRV). To investi...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.215 |
| _version_ | 1797374975971164160 |
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| author | Giuseppe Miceli Grazia Pennisi Luisa Agnello Vincenza Calvaruso Emanuele Amodio Alessandra Casuccio Chiara Pintus Maria Grazia Basso Rosaria Maria Pipitone Mario Daidone Rossella Zito Giulia Lupo Salvatore Petta Giuseppe Cabibbo Marcello Ciaccio Stefania Grimaudo Antonio CraxÌ Antonino Tuttolomondo |
| author_facet | Giuseppe Miceli Grazia Pennisi Luisa Agnello Vincenza Calvaruso Emanuele Amodio Alessandra Casuccio Chiara Pintus Maria Grazia Basso Rosaria Maria Pipitone Mario Daidone Rossella Zito Giulia Lupo Salvatore Petta Giuseppe Cabibbo Marcello Ciaccio Stefania Grimaudo Antonio CraxÌ Antonino Tuttolomondo |
| author_sort | Giuseppe Miceli |
| collection | DOAJ |
| description | Abstract Background The autonomic nervous system is linked to hyperdynamic circulation in cirrhosis and several studies have highlighted the crucial role that systemic inflammation elicits in altering sympathovagal equilibrium with the consequent reduction in heart rate variability (HRV). To investigate the correlation between time‐domain HRV parameters, serum cytokines concentrations and portal hypertension, we studied a cohort of patients with cirrhosis, accounting for etiology and treatments. Methods In this cross‐sectional, observational cohort study, 107 outpatients with non‐alcoholic cirrhosis were assessed consecutively by abdominal ultrasound and by upper gastrointestinal endoscopy to search for esophagogastric varices. 24‐h electrocardiogram Holter monitoring with time‐domain HRV measurement (square root of the mean of successive differences of Normal‐to‐Normal [NN] [RMSSD], standard deviation or the square root of variance [SDNN] and standard deviation of the means of the NN intervals calculated over a 5‐min period [SDANN]) was performed and serum concentrations of osteopontin (OPN), interleukin (IL)‐22, IL‐6, IL‐1Ra and IL‐17 were obtained in all patients. Results IL‐6, OPN, IL‐22 and IL‐1Ra concentrations in cirrhotic patients were associated with disease severity expressed by Child‐Pugh and MELD score, to some portal hypertension's indirect signs and some of its complications. A significant increase in systemic concentrations of OPN in patients with hepatocellular carcinoma was encountered. SDANN and SDNN values were indirectly related to serum levels of IL‐6, OPN, IL‐1Ra and IL‐22. Conclusions This study underlines the interaction between the alteration of the ANS and the activation of inflammatory pathways that characterize cirrhosis taking into account clinical characteristics and treatments. |
| first_indexed | 2024-03-08T19:15:33Z |
| format | Article |
| id | doaj.art-6a208612d31c44d4b2605b5da78c5e6d |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-08T19:15:33Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-6a208612d31c44d4b2605b5da78c5e6d2023-12-27T07:32:36ZengWileyClinical and Translational Discovery2768-06222023-12-0136n/an/a10.1002/ctd2.215Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severityGiuseppe Miceli0Grazia Pennisi1Luisa Agnello2Vincenza Calvaruso3Emanuele Amodio4Alessandra Casuccio5Chiara Pintus6Maria Grazia Basso7Rosaria Maria Pipitone8Mario Daidone9Rossella Zito10Giulia Lupo11Salvatore Petta12Giuseppe Cabibbo13Marcello Ciaccio14Stefania Grimaudo15Antonio CraxÌ16Antonino Tuttolomondo17Department of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyDepartment of Health promotion Mother and Child Care, Internal Medicine and Medical specialties (ProMISE), Università degli Studi di Palermo PalermoItalyAbstract Background The autonomic nervous system is linked to hyperdynamic circulation in cirrhosis and several studies have highlighted the crucial role that systemic inflammation elicits in altering sympathovagal equilibrium with the consequent reduction in heart rate variability (HRV). To investigate the correlation between time‐domain HRV parameters, serum cytokines concentrations and portal hypertension, we studied a cohort of patients with cirrhosis, accounting for etiology and treatments. Methods In this cross‐sectional, observational cohort study, 107 outpatients with non‐alcoholic cirrhosis were assessed consecutively by abdominal ultrasound and by upper gastrointestinal endoscopy to search for esophagogastric varices. 24‐h electrocardiogram Holter monitoring with time‐domain HRV measurement (square root of the mean of successive differences of Normal‐to‐Normal [NN] [RMSSD], standard deviation or the square root of variance [SDNN] and standard deviation of the means of the NN intervals calculated over a 5‐min period [SDANN]) was performed and serum concentrations of osteopontin (OPN), interleukin (IL)‐22, IL‐6, IL‐1Ra and IL‐17 were obtained in all patients. Results IL‐6, OPN, IL‐22 and IL‐1Ra concentrations in cirrhotic patients were associated with disease severity expressed by Child‐Pugh and MELD score, to some portal hypertension's indirect signs and some of its complications. A significant increase in systemic concentrations of OPN in patients with hepatocellular carcinoma was encountered. SDANN and SDNN values were indirectly related to serum levels of IL‐6, OPN, IL‐1Ra and IL‐22. Conclusions This study underlines the interaction between the alteration of the ANS and the activation of inflammatory pathways that characterize cirrhosis taking into account clinical characteristics and treatments.https://doi.org/10.1002/ctd2.215cirrhosiscytokinesheart rate variabilityinflammationportal hypertensionvarices bleeding |
| spellingShingle | Giuseppe Miceli Grazia Pennisi Luisa Agnello Vincenza Calvaruso Emanuele Amodio Alessandra Casuccio Chiara Pintus Maria Grazia Basso Rosaria Maria Pipitone Mario Daidone Rossella Zito Giulia Lupo Salvatore Petta Giuseppe Cabibbo Marcello Ciaccio Stefania Grimaudo Antonio CraxÌ Antonino Tuttolomondo Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity Clinical and Translational Discovery cirrhosis cytokines heart rate variability inflammation portal hypertension varices bleeding |
| title | Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity |
| title_full | Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity |
| title_fullStr | Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity |
| title_full_unstemmed | Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity |
| title_short | Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity |
| title_sort | inflammation and autonomic balance in cirrhosis association between sympathetic nervous system and osteopontin interleukin 22 interleukin 6 and interleukin 1ra concentrations according to portal hypertension and disease severity |
| topic | cirrhosis cytokines heart rate variability inflammation portal hypertension varices bleeding |
| url | https://doi.org/10.1002/ctd2.215 |
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