Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane (TM) r...

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Bibliographic Details
Main Authors: Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
M. tuberculosis
adenylyl cyclase
membrane protein
cyclic adenosine monophosphate
signalling
Online Access:https://elifesciences.org/articles/77032

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