Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Ageing is associated with excessive free brain iron, which may induce oxidative stress and neuroinflammation, likely causing cognitive deficits. Lack of dopamine may be a factor behind the increase of iron with advancing age, as it has an important role in cellular iron homoeostasis. We investigated...

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Príomhchruthaitheoirí: Jonatan Gustavsson, Goran Papenberg, Farshad Falahati, Erika J. Laukka, Grégoria Kalpouzos
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Frontiers Media S.A. 2022-04-01
Sraith:Frontiers in Human Neuroscience
Ábhair:
brain iron
COMT
working memory
longitudinal
ageing
QSM
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fnhum.2022.838228/full

Ar líne

https://www.frontiersin.org/articles/10.3389/fnhum.2022.838228/full

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