Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Ageing is associated with excessive free brain iron, which may induce oxidative stress and neuroinflammation, likely causing cognitive deficits. Lack of dopamine may be a factor behind the increase of iron with advancing age, as it has an important role in cellular iron homoeostasis. We investigated...

Cijeli opis

Bibliografski detalji
Glavni autori: Jonatan Gustavsson, Goran Papenberg, Farshad Falahati, Erika J. Laukka, Grégoria Kalpouzos
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2022-04-01
Serija:Frontiers in Human Neuroscience
Teme:
brain iron
COMT
working memory
longitudinal
ageing
QSM
Online pristup:https://www.frontiersin.org/articles/10.3389/fnhum.2022.838228/full

Internet

https://www.frontiersin.org/articles/10.3389/fnhum.2022.838228/full

Slični predmeti