Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans
BackgroundBrain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH.MethodsWe performed ret...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnint.2023.1207610/full |
| _version_ | 1797756505875808256 |
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| author | Daniel L. Cooke Hui Shen Madhavi Duvvuri Daniel Thompson Thomas Neylan William Wolfe Steven Hetts Bruce Ovbiagele Mary Whooley Beth Cohen |
| author_facet | Daniel L. Cooke Hui Shen Madhavi Duvvuri Daniel Thompson Thomas Neylan William Wolfe Steven Hetts Bruce Ovbiagele Mary Whooley Beth Cohen |
| author_sort | Daniel L. Cooke |
| collection | DOAJ |
| description | BackgroundBrain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH.MethodsWe performed retrospective, case-control study of a National Veterans Affairs population with two experimental groups (aneurysm-only and aneurysmal SAH) and 10-fold controls per group matched by age, date, and clinical data source. The studied the presence of 4 psychiatric disorders: Posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety disorder (GAD), and other mood disorders. Our main outcomes Unadjusted and multivariable adjusted ORs of PTSD, MDD, GAD, and mood disorders within aneurysm-only and aSAH groups.ResultsIn 6,320,789 US Veterans who were enrolled for at least 5 years in Medicare and/or the Veterans Health Administration, we identified 35,094 cases of aneurysm without SAH and 5,749 cases of aneurysm with SAH between 1/2005 and 12/2019. In analyses adjusted for sex, hypertension, and tobacco use, patients with aneurysm were more likely than matched controls to have a history of PTSD (OR 1.48), MDD (OR 1.33), GAD (OR 1.26), and other mood disorders (OR 1.34) (all p-values < 0.0001). Similarly, patients with aSAH were more likely than controls to have a history of PTSD (OR 1.35), MDD (OR 1.38), GAD (OR 1.18), and other mood disorders (OR 1.30) (all p-values < 0.0001).ConclusionThe study, the largest of its kind, further suggests links between psychiatric disorders and stroke. This is important as patients with aneurysms are not routinely screened for such psychiatric risk factors. Additional research on this topic could lead to novel strategies to improve stroke prevention. |
| first_indexed | 2024-03-12T18:01:24Z |
| format | Article |
| id | doaj.art-6a264e28aa384733b5a910d9483cf110 |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-03-12T18:01:24Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-6a264e28aa384733b5a910d9483cf1102023-08-02T09:59:13ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452023-08-011710.3389/fnint.2023.12076101207610Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veteransDaniel L. Cooke0Hui Shen1Madhavi Duvvuri2Daniel Thompson3Thomas Neylan4William Wolfe5Steven Hetts6Bruce Ovbiagele7Mary Whooley8Beth Cohen9Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesSan Francisco Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Neurology, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Medicine, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Medicine, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, United StatesBackgroundBrain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH.MethodsWe performed retrospective, case-control study of a National Veterans Affairs population with two experimental groups (aneurysm-only and aneurysmal SAH) and 10-fold controls per group matched by age, date, and clinical data source. The studied the presence of 4 psychiatric disorders: Posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety disorder (GAD), and other mood disorders. Our main outcomes Unadjusted and multivariable adjusted ORs of PTSD, MDD, GAD, and mood disorders within aneurysm-only and aSAH groups.ResultsIn 6,320,789 US Veterans who were enrolled for at least 5 years in Medicare and/or the Veterans Health Administration, we identified 35,094 cases of aneurysm without SAH and 5,749 cases of aneurysm with SAH between 1/2005 and 12/2019. In analyses adjusted for sex, hypertension, and tobacco use, patients with aneurysm were more likely than matched controls to have a history of PTSD (OR 1.48), MDD (OR 1.33), GAD (OR 1.26), and other mood disorders (OR 1.34) (all p-values < 0.0001). Similarly, patients with aSAH were more likely than controls to have a history of PTSD (OR 1.35), MDD (OR 1.38), GAD (OR 1.18), and other mood disorders (OR 1.30) (all p-values < 0.0001).ConclusionThe study, the largest of its kind, further suggests links between psychiatric disorders and stroke. This is important as patients with aneurysms are not routinely screened for such psychiatric risk factors. Additional research on this topic could lead to novel strategies to improve stroke prevention.https://www.frontiersin.org/articles/10.3389/fnint.2023.1207610/fullaneurysmstrokeposttraumatic stress disorder (PTSD)depressiongeneralized anxiety disorder |
| spellingShingle | Daniel L. Cooke Hui Shen Madhavi Duvvuri Daniel Thompson Thomas Neylan William Wolfe Steven Hetts Bruce Ovbiagele Mary Whooley Beth Cohen Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans Frontiers in Integrative Neuroscience aneurysm stroke posttraumatic stress disorder (PTSD) depression generalized anxiety disorder |
| title | Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| title_full | Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| title_fullStr | Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| title_full_unstemmed | Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| title_short | Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| title_sort | association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans |
| topic | aneurysm stroke posttraumatic stress disorder (PTSD) depression generalized anxiety disorder |
| url | https://www.frontiersin.org/articles/10.3389/fnint.2023.1207610/full |
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