Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery
Background: In a trial to overcome the adverse effects of pneumoperitoneum during laparoscopic gastric bypass surgery (GBP) on renal function this study investigated the effects of third generation HES 130/0.4 (6%) on renal function and blood loss during laparoscopic GBP. Patients and methods: This...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-01-01
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| Series: | Egyptian Journal of Anaesthesia |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110184915001257 |
| _version_ | 1818996151504863232 |
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| author | Sabry M. Amin Sameh M. Fathy |
| author_facet | Sabry M. Amin Sameh M. Fathy |
| author_sort | Sabry M. Amin |
| collection | DOAJ |
| description | Background: In a trial to overcome the adverse effects of pneumoperitoneum during laparoscopic gastric bypass surgery (GBP) on renal function this study investigated the effects of third generation HES 130/0.4 (6%) on renal function and blood loss during laparoscopic GBP.
Patients and methods: This study was carried out on 83 adult patients of both sexes scheduled for (GBP) surgery. Patients were randomly classified into Group I (42): received HES 130/0.4 10 ml/kg to a maximum volume 1000 ml, and Group II (41): received ringer acetate solution 10 ml/kg to a maximum volume 1000 ml within 30 min pre-operatively.
Mean arterial blood pressure (MABP) and heart rate (HR) were measured before starting of fluid infusion, and every 15 min till the end of surgery. Blood loss was assessed intraoperatively and postoperatively.
Intraoperative urine output was observed. Renal functions (blood urea, serum creatinine, and creatine clearance) were evaluated preoperatively and after 24 h postoperatively.
Results: Intraoperative and postoperative blood loss was comparable in both groups. Changes in mean arterial blood pressure (MABP), and heart rate (HR) were comparable in both groups except significant increase in MABP in group I from 30 min till 150 min intraoperatively (p values were 0.04, 0.03, 0.02, 0.04, 0.01, respectively). Creatinine clearance increased significantly at postoperative assessment time in group I, (p = 0.04). There was no significant difference between both groups regarding serum creatinine and blood urea. Intraoperative urine output significantly increased in group I, (p = 0.02).
Conclusion: Infusion of HES 130/0.4 has role in prevention of oliguria and provides renal protection without effect on hemostasis and intraoperative or postoperative blood loss. |
| first_indexed | 2024-12-20T21:25:11Z |
| format | Article |
| id | doaj.art-6a27ff2b92d94fb0a5f7ecd8000930d2 |
| institution | Directory Open Access Journal |
| issn | 1110-1849 |
| language | English |
| last_indexed | 2024-12-20T21:25:11Z |
| publishDate | 2016-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Egyptian Journal of Anaesthesia |
| spelling | doaj.art-6a27ff2b92d94fb0a5f7ecd8000930d22022-12-21T19:26:11ZengTaylor & Francis GroupEgyptian Journal of Anaesthesia1110-18492016-01-01321778110.1016/j.egja.2015.11.006Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgerySabry M. AminSameh M. FathyBackground: In a trial to overcome the adverse effects of pneumoperitoneum during laparoscopic gastric bypass surgery (GBP) on renal function this study investigated the effects of third generation HES 130/0.4 (6%) on renal function and blood loss during laparoscopic GBP. Patients and methods: This study was carried out on 83 adult patients of both sexes scheduled for (GBP) surgery. Patients were randomly classified into Group I (42): received HES 130/0.4 10 ml/kg to a maximum volume 1000 ml, and Group II (41): received ringer acetate solution 10 ml/kg to a maximum volume 1000 ml within 30 min pre-operatively. Mean arterial blood pressure (MABP) and heart rate (HR) were measured before starting of fluid infusion, and every 15 min till the end of surgery. Blood loss was assessed intraoperatively and postoperatively. Intraoperative urine output was observed. Renal functions (blood urea, serum creatinine, and creatine clearance) were evaluated preoperatively and after 24 h postoperatively. Results: Intraoperative and postoperative blood loss was comparable in both groups. Changes in mean arterial blood pressure (MABP), and heart rate (HR) were comparable in both groups except significant increase in MABP in group I from 30 min till 150 min intraoperatively (p values were 0.04, 0.03, 0.02, 0.04, 0.01, respectively). Creatinine clearance increased significantly at postoperative assessment time in group I, (p = 0.04). There was no significant difference between both groups regarding serum creatinine and blood urea. Intraoperative urine output significantly increased in group I, (p = 0.02). Conclusion: Infusion of HES 130/0.4 has role in prevention of oliguria and provides renal protection without effect on hemostasis and intraoperative or postoperative blood loss.http://www.sciencedirect.com/science/article/pii/S1110184915001257Laparoscopic gastric bypass surgeryHydroxyethyl starch (130/0.4)HemodynamicBlood lossRenal function |
| spellingShingle | Sabry M. Amin Sameh M. Fathy Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery Egyptian Journal of Anaesthesia Laparoscopic gastric bypass surgery Hydroxyethyl starch (130/0.4) Hemodynamic Blood loss Renal function |
| title | Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery |
| title_full | Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery |
| title_fullStr | Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery |
| title_full_unstemmed | Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery |
| title_short | Effect of preoperative hypervolemic hemodilution with hydroxyethyl starch (130/0.4) on hemodynamics, blood loss and renal function after laparoscopic gastric bypass surgery |
| title_sort | effect of preoperative hypervolemic hemodilution with hydroxyethyl starch 130 0 4 on hemodynamics blood loss and renal function after laparoscopic gastric bypass surgery |
| topic | Laparoscopic gastric bypass surgery Hydroxyethyl starch (130/0.4) Hemodynamic Blood loss Renal function |
| url | http://www.sciencedirect.com/science/article/pii/S1110184915001257 |
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